120-05-8

Basic information

• Product Name: SULFURETIN
• Synonyms: SULFURETIN;6,3',4'-TRIHYDROXYAURONE;3',4',6-TRIHYDROXYAURONE;2-(3,4-dihydroxybenzylidene)-6-hydroxy-2H-benzofuran-3-one;(Z)-2-[(3,4-dihydroxyphenyl)methylene]-6-hydroxy-2H-benzofuran-3-one;SULPHURETIN;SULFURETIN WITH HPLC;SULFURETIN hplc
• CAS NO: 120-05-8
• Molecular Formula: C₁₅H₁₀O₅
• Molecular Weight: 270.24
• EINECS: 204-366-4
• Product Categories: Aurones
• Mol File: 120-05-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 295°C
• Boiling Point: 585 °C at 760 mmHg
• Flash Point: 228.8 °C
• Appearance: /
• Density: 1.597 g/cm³
• Vapor Pressure: 2.79E-14mmHg at 25°C
• Refractive Index: 1.793
• CAS DataBase Reference: SULFURETIN(CAS DataBase Reference)
• NIST Chemistry Reference: SULFURETIN(120-05-8)
• EPA Substance Registry System: SULFURETIN(120-05-8)

Safety Data

• Hazardous Substances Data: 120-05-8(Hazardous Substances Data)

Usage

General Description

Sulfuretin is a natural organic compound that belongs to the flavonoid group of chemicals. It is found in various plants, including Sophora japonica and Rhus succedanea, and is responsible for the yellow and orange pigmentation in some flowers and fruits. Sulfuretin has been studied for its potential medicinal and therapeutic properties, including antioxidant, anti-inflammatory, and anti-cancer effects. It has also shown promising results in the treatment of skin conditions such as dermatitis and eczema. Additionally, sulfuretin has been investigated for its role in aiding insulin sensitivity and reducing the risk of diabetes. Research on sulfuretin is ongoing to further explore its potential applications in medicine and healthcare.

InChI:InChI=1/C15H10O5/c16-9-2-3-10-13(7-9)20-14(15(10)19)6-8-1-4-11(17)12(18)5-8/h1-7,16-18H/b14-6+

Upstream product

• 6272-26-0 6-hydroxybenzofuran-3-one 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 113739-06-3 methyl 6-hydroxybenzofuran-3(2H)-one 
• 108-46-3 recorcinol 
• 121-32-4 4-hydroxy-3-ethoxybenzaldehyde 
• 25015-92-3 2-chloro-1-(2,4-dihydroxyphenyl)ethanone 
• 36685-46-8 (Z)-2-(3,4-dimethoxybenzylidene)-6-methoxybenzofuran-3(2H)-one 
• 1360878-02-9 sulphuretin 3'-O-β-glucopyranoside 

Downstream Products

• 1005324-89-9 2-(3,4-dihydroxybenzyl)-6-hydroxybenzofuran-3(2H)-one 
• 5965-85-5 6-acetoxy-2-((Z)-3,4-diacetoxy-benzylidene)-benzofuran-3-one 

Related news

SULFURETIN (cas 120-05-8) isolated from heartwood of Rhus verniciflua inhibits LPS-induced inducible nitric oxide synthase, cyclooxygenase-2, and pro-inflammatory cytokines expression via the down-regulation of NF-κB in RAW 264.7 murine macrophage cells09/05/2019

It has been reported that Rhus verniciflua exhibits anti-inflammatory, anti-oxidant and anti-cancer activities. However, little is known about biological activity of sulfuretin, a flavonoid isolated from R. verniciflua. In the present study, we investigated the anti-inflammatory effect and the u...detailed

Anti-inflammatory effects of SULFURETIN (cas 120-05-8) from Rhus verniciflua Stokes via the induction of heme oxygenase-1 expression in murine macrophages09/04/2019

Rhus verniciflua Stokes (Anacardiaceae) has traditionally been used as an ingredient in East Asian medicines used to treat oxidative damage and cancer. Sulfuretin is one of the major flavonoid components isolated from R. verniciflua. In the present study, we isolated sulfuretin from R. vernicifl...detailed

SULFURETIN (cas 120-05-8) inhibits 6-hydroxydopamine-induced neuronal cell death via reactive oxygen species-dependent mechanisms in human neuroblastoma SH-SY5Y cells09/02/2019

Sulfuretin, a potent anti-oxidant, has been thought to provide health benefits by decreasing the risk of oxidative stress-related diseases. In this study, we investigated the mechanisms of sulfuretin protection of neuronal cells from cell death induced by the Parkinson’s disease (PD)-related ne...detailed

SULFURETIN (cas 120-05-8) attenuates allergic airway inflammation in mice08/31/2019

Sulfuretin is one of the main flavonoids produced by Rhus verniciflua, which is reported to inhibit the inflammatory response by suppressing the NF-κB pathway. Because NF-κB activation plays a pivotal role in the pathogenesis of allergic airway inflammation, we here examined the effect of sulf...detailed

Relevant articles and documents

Design, synthesis and biological activities of dihydroaurones

To widen aurones applicability in achromatic food and cosmetic applications, a series of dihydroaurones were designed to mimic natural aurones as well as synthetic aurones. Dihydroaurones have been synthesized from the corresponding aurones by hydrogenation. These dihydroaurones and their corresponding aurones were screened for antioxidant, anti-inflammatory and tyrosinase enzyme inhibitory activity. Synthesized dihydroaurones (3b-f) displayed superior antioxidant activity in superoxide free radical scavenging assay than the standard gallic acid. Dihydroaurones (3b-f) also exhibited significant tyrosinase enzyme inhibitory activity and two dihydroaurones (3h, 3j) showed promising 5-lipoxygenase inhibitory activity.

Aurones as new porcine pancreatic α-amylase inhibitors

Background: Aurones, (Z)-2-benzylidenebenzofuran-3-one derivatives, are naturally-occurring structural isomers of flavones, with promising pharmacological potential. Methods: In this study, the structural requirements for the inhibition of porcine pancreatic α-amylase by hydroxylated or methoxylated aurone derivatives were investigated by assessing their in vitro biological activities against porcine pancreatic α-amylase. Results: The structure-activity relationship of these inhibitors based on both in vitro and in silico findings showed that the hydrogen bonds between the OH groups of the A or B ring of (Z)-benzylidenebenzofuran-3-one derivatives and the catalytic residues of the binding site are crucial for their inhibitory activities. Conclusion: It seems that the OH groups in aurones inhibit α-amylase in a manner similar to that of OH groups in flavones and flavonols.

Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet β-cells from apoptosis

Death-associated protein kinase-related apoptosis-inducing kinase-2 (DRAK2) is a serine/threonine kinase that plays a key role in a wide variety of cell death signaling pathways. Inhibition of DRAK2 was found to efficiently protect islet β-cells from apoptosis and hence DRAK2 inhibitors represent a promising therapeutic strategy for the treatment of diabetes. Only very few chemical entities targeting DRAK2 are currently known. We carried out a high throughput screening and identified compound 4 as a moderate DRAK2 inhibitor with an IC50value of 3.15?μM. Subsequent SAR studies of hit compound 4 led to the development of novel benzofuran-3(2H)-one series of DRAK2 inhibitors with improved potency and favorable selectivity profiles against 26 selected kinases. Importantly, most potent compounds 40 (IC50?=?0.33?μM) and 41 (IC50?=?0.25?μM) were found to protect islet β-cells from apoptosis in dose-dependent manners. These data support the notion that small molecule inhibitors of DRAK2 represents a promising strategy for the treatment of diabetes.