120-35-4Relevant articles and documents
Preparation method of red base KD
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Paragraph 0021; 0022; 0023; 0024, (2018/04/01)
The invention discloses a method for producing red base KD (3-amino-4-methoxybenzanilide) from 3-nitro-4-methoxybenzoic acid. The method comprises the following steps: taking the 3-nitro-4-methoxybenzoic acid and aniline as raw materials, controlling under certain conditions for shrinkage and condensation reaction in a reactor with a jacket heat conduction oil heating function to obtain a condensate, performing reduction reaction on the condensate to obtain a red base KD coarse product, reducing the red base KD coarse product and obtaining a red base KD finished product through acid dissolution, de-coloring, filtering, neutralizing, suction filtration, rinsing and drying. The method disclosed by the invention has the advantages that the high-purity 3-nitro-4-methoxybenzoic acid is adoptedas the raw material, process conditions for reaction points are controlled, and the most appropriate process ratio is found, so that the product yield and the quality are improved. Therefore, 'three wastes' are greatly reduced, wastes, waste gas and waste water are easy to treat, the process is simpler, the operation is safer, the yield is improved greatly, the energy consumption is reduced, and ared 175 series product as a produced pigment is more bright in color; according to the method disclosed by the invention, the yield is 95 percent or higher, and the content is up to 99 percent or higher.
Preparation method of 3-amino-4-methoxybenzaniline
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Paragraph 0018, (2016/10/17)
The invention relates to a preparation method of 3-amino-4-methoxybenzaniline.The preparation method includes the steps that 3-nitro-4-X-benzoic acid reacts with aniline under a reaction agent condition to obtain 3-nitro-4-X-benzanilide; 2, 3-nitro-4-X-benzanilide reacts with methyl alcohol under the presence of alkaline reagent to obtain 3-nitro-4 methoxybenzaniline; reduction reaction is performed with treatment or without treatment, so that 3-amino-4-methoxybenzaniline is obtained.The method is high in product yield, low in cost, good in quality and convenient to industrialize and meets the requirement for environmentally-friendly production.
Synthesis and antiviral activity of substituted bisaryl amide compounds as novel influenza virus inhibitors
Hao, Lan-Hu,Li, Yan-Ping,He, Wei-Ying,Wang, Hui-Qiang,Shan, Guang-Zhi,Jiang, Jian-Dong,Li, Yu-Huan,Li, Zhuo-Rong
, p. 117 - 124 (2012/11/07)
The influenza virus is a persistent cause of mortality and morbidity on an annual basis and thus presents itself as an important target for pharmaceutical investigation. In this work, substituted bisaryl amide compounds were found to be a new class of potential anti-influenza agents, and a series of substituted bisaryl amide compounds were synthesised and evaluated for their anti-influenza virus activities. The analysis of the results produced a preliminary structure-activity relationship study (SAR). Compounds 1a, 1g, 1h, 1j, 1l and 1n exhibited clear antiviral activities against the influenza A (A/Guangdong Luohu/219/2006, H1N1) virus with 50% inhibitory concentrations (IC50) for virus growth ranging from 12.5 to 59.0 μM. Specifically, compound 1j also possessed antiviral activity against both oseltamivir-resistant influenza (A/Jinnan/15/2009) virus and influenza B (B/Jifang/13/97) virus with IC 50 values of 9.2 μM and 21.4 μM, respectively. Compound 1j is thus worth further investigation as an anti-influenza virus candidate.