120-35-4

Usage

Uses

Used in Medical Industry:
3-Amino-4-methoxybenzanilide is used as a component in the preparation method of Cyanate resin-based near-zero expansion composite material truss rod. This truss rod is utilized in orthopedic surgeries, specifically for the fixation of bones, providing stability and support during the healing process.
Used in Chemical Industry:
3-Amino-4-methoxybenzanilide is used as an intermediate in the synthesis of dyes, pharmaceuticals, and other organic chemicals. Its unique chemical structure allows it to be a versatile building block for the development of various compounds with different properties and applications.

InChI:InChI=1/C14H14N2O2/c1-18-13-8-7-10(9-12(13)15)14(17)16-11-5-3-2-4-6-11/h2-9H,15H2,1H3,(H,16,17)

Upstream product

• 2840-26-8 3-amino-4-methoxybenzoic acid 
• 62-53-3 aniline 
• 96-99-1 4-chloro-3-nitrobenzoate 
• 97-32-5 3-nitro-4-methoxybenzanilide 
• 41870-24-0 (4-methoxy-3-nitrophenyl)methanol 
• 89-41-8 4-methoxy-3-nitrobenzoic acid 
• 98-88-4 benzoyl chloride 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 137-52-0 N-[2-methoxy-5-chlorophenyl]-3-hydroxy-2-naphthalene carboxamide 

Downstream Products

• 228422-87-5 4-methoxy-3-phenylamino-N-phenylbenzamide 

Relevant academic research and scientific papers

Preparation method of red base KD

The invention discloses a method for producing red base KD (3-amino-4-methoxybenzanilide) from 3-nitro-4-methoxybenzoic acid. The method comprises the following steps: taking the 3-nitro-4-methoxybenzoic acid and aniline as raw materials, controlling under certain conditions for shrinkage and condensation reaction in a reactor with a jacket heat conduction oil heating function to obtain a condensate, performing reduction reaction on the condensate to obtain a red base KD coarse product, reducing the red base KD coarse product and obtaining a red base KD finished product through acid dissolution, de-coloring, filtering, neutralizing, suction filtration, rinsing and drying. The method disclosed by the invention has the advantages that the high-purity 3-nitro-4-methoxybenzoic acid is adoptedas the raw material, process conditions for reaction points are controlled, and the most appropriate process ratio is found, so that the product yield and the quality are improved. Therefore, 'three wastes' are greatly reduced, wastes, waste gas and waste water are easy to treat, the process is simpler, the operation is safer, the yield is improved greatly, the energy consumption is reduced, and ared 175 series product as a produced pigment is more bright in color; according to the method disclosed by the invention, the yield is 95 percent or higher, and the content is up to 99 percent or higher.

Synthesizing method of dye compound 3-amino-4-methoxy benzanilide

The invention relates to a synthesizing method of a dye compound 3-amino-4-methoxy benzanilide. The synthesizing method includes the steps of S1, in organic solvent and in the presence of composite catalyst, oxidizing agent and organic ligand, allowing a compound as shown in formula (I) and a compound as shown in formula (II) to react with each other; S2, directly adding reducing agent to perform reduction reaction after the reaction of the step S1, and performing post-treatment to obtain the 3-amino-4-methoxy benzanilide. The synthesizing method has the advantages that by using an appropriate reaction substrate and the comprehensive selection and coordination of the catalyst, the oxidizing agent, the organic ligand and the organic solvent, the 3-amino-4-methoxy benzanilide can be synthesized in a high-yield manner; in addition, the reaction flow is shortened, and the method is promising in application prospect and good in production potential.

Preparation method of 3-amino-4-methoxybenzaniline

The invention relates to a preparation method of 3-amino-4-methoxybenzaniline.The preparation method includes the steps that 3-nitro-4-X-benzoic acid reacts with aniline under a reaction agent condition to obtain 3-nitro-4-X-benzanilide; 2, 3-nitro-4-X-benzanilide reacts with methyl alcohol under the presence of alkaline reagent to obtain 3-nitro-4 methoxybenzaniline; reduction reaction is performed with treatment or without treatment, so that 3-amino-4-methoxybenzaniline is obtained.The method is high in product yield, low in cost, good in quality and convenient to industrialize and meets the requirement for environmentally-friendly production.

Synthesis and antiviral activity of N-phenylbenzamide derivatives, a novel class of enterovirus 71 inhibitors

A series of novel N-phenylbenzamide derivatives were synthesized and their anti-EV 71 activities were assayed in vitro. Among the compounds tested, 3-amino-N-(4- bromophenyl)-4-methoxybenzamide (1e) was active against the EV 71 strains tested at low micromolar concentrations, with IC50 values ranging from 5.7 ± 0.8-12 ± 1.2 μM, and its cytotoxicity to Vero cells (TC50 = 620 ± 0.0 μM) was far lower than that of pirodavir (TC50 = 31 ± 2.2 μM). Based on these results, compound 1e is a promising lead compound for the development of anti-EV 71 drugs.

Synthesis and antiviral activity of substituted bisaryl amide compounds as novel influenza virus inhibitors

The influenza virus is a persistent cause of mortality and morbidity on an annual basis and thus presents itself as an important target for pharmaceutical investigation. In this work, substituted bisaryl amide compounds were found to be a new class of potential anti-influenza agents, and a series of substituted bisaryl amide compounds were synthesised and evaluated for their anti-influenza virus activities. The analysis of the results produced a preliminary structure-activity relationship study (SAR). Compounds 1a, 1g, 1h, 1j, 1l and 1n exhibited clear antiviral activities against the influenza A (A/Guangdong Luohu/219/2006, H1N1) virus with 50% inhibitory concentrations (IC50) for virus growth ranging from 12.5 to 59.0 μM. Specifically, compound 1j also possessed antiviral activity against both oseltamivir-resistant influenza (A/Jinnan/15/2009) virus and influenza B (B/Jifang/13/97) virus with IC 50 values of 9.2 μM and 21.4 μM, respectively. Compound 1j is thus worth further investigation as an anti-influenza virus candidate.

A GROUP OF AMINO SUBSTITUTED BENZOYL DERIVATIVES AND THEIR PREPARATION AND THEIR USE

A group of amino substituted benzoyl derivatives, their preparation and their use. The screening and research on an antiviral drug with hA3G/Vif as a target point proves that the 3-amino benzoyl derivatives not only have the combined activity for the hA3G/Vif, but also have a function of inhibiting replication of viruses. The present invention provides the possible breakthrough progress for the problem of HIV drug resistance, thereby providing a novel clinical antiviral drug which has higher efficiency.

Group of amino substituted benzoyl derivatives and their preparation and their use

A group of amino substituted benzoyl derivatives, their preparation and their use. The screening and research on an antiviral drug with hA3G/Vif as a target point proves that the 3-amino benzoyl derivatives not only have the combined activity for the hA3G/Vif, but also have a function of inhibiting replication of viruses. The present invention provides the possible breakthrough progress for the problem of HIV drug resistance, thereby providing a novel clinical antiviral drug which has higher efficiency.

HIGH-PURITY NAPHTHOL AS PIGMENTS

Naphthol AS pigments of formula (IV) have a maximum content of the secondary components (1) to (5) defined by the following upper limits (see the table).

Pigment compositions for solvent and water-based ink systems and the methods for producing them

This invention is an azo pigment composition containing a water insoluble metal salt of a water soluble polymer; a method of preparing said composition and ink compositions prepared from said azo pigment compositions.

Azo pigment compositions and process for their preparation

This invention is that of an azo pigment composition containing about 1 to 10 percent by weight of a nonionic alkyl polyglycoside dispersing agent. The polyglycosides useful in the invention have the general formulae: wherein: M is an oxygen, sulfur, nitrogen phosphorous or silicon atom; n is an integer from 8 to 18, preferably 8 to 11 and X represents the number average degree of polymerization having a numerical value from about 1 to about 2. These azo pigment compositions are prepared by conducting the azo pigment coupling reaction in the presence of said alkyl polyglycoside. The resulting pigment exhibit superior application properties in water based ink systems.