1200-15-3

Usage

Uses

Used in Chemical Synthesis:
2-[(4-Chlorobenzyl)oxy]-1-ethanol is used as an intermediate in chemical synthesis for the production of various organic compounds. Its unique molecular structure allows it to participate in a range of chemical reactions, facilitating the synthesis of target molecules.
Used in Solvent Applications:
In the chemical industry, 2-[(4-Chlorobenzyl)oxy]-1-ethanol is used as a solvent for various organic and inorganic substances. Its ability to dissolve a wide range of materials makes it a valuable component in the formulation of solvents for different applications.
Used in Pharmaceutical Industry:
2-[(4-Chlorobenzyl)oxy]-1-ethanol is utilized as a building block in the development of pharmaceutical compounds. Its structural features enable it to be incorporated into drug molecules, potentially enhancing their therapeutic properties and improving their pharmacokinetic profiles.
Used in Soil Disinfection:
As a member of the organochlorine family, 2-[(4-Chlorobenzyl)oxy]-1-ethanol can be employed as a soil disinfectant. Its ability to control soil-borne pathogens and pests contributes to improved crop health and productivity.

InChI:InChI=1/C9H11ClO2/c10-9-3-1-8(2-4-9)7-12-6-5-11/h1-4,11H,5-7H2

Upstream product

• 107-21-1 ethylene glycol 
• 622-95-7 4-chlorobenzyl bromide 
• 2403-54-5 2-(4-chlorophenyl)-1,3-dioxolane 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 7388-28-5 sodium ethane-1,2-diolate 

Downstream Products

• 2403-54-5 2-(4-chlorophenyl)-1,3-dioxolane 
• 99058-26-1 2-(4-chloro-benzyloxy)-ethyl thiocyanate 
• 29904-52-7 (2-chloro-ethyl)-(4-chloro-benzyl)-ether 
• 488123-96-2 [(p-chlorobenzyl)oxy]acetaldehyde 
• 925419-05-2 methanesulfonic acid 2-(4-chloro-benzyloxy)-ethyl ester 
• 83621-03-8 1-{[(2-bromoethyl)oxy]methyl}-4-chlorobenzene 

Relevant academic research and scientific papers

(Z)-Selective enol triflation of α-alkoxyacetoaldehydes: Application to synthesis of (Z)-allylic alcohols via cross-coupling reaction and [1,2]-wittig rearrangement

The stereoselective transformation of α-alkoxyacetoaldehydes to the corresponding (Z)-vinyl triflates was achieved by treatment with phenyl triflimide and DBU. The stereochemistry was explained by the "syn-effect," which was attributed primarily to an σ → π interaction. The β-alkoxy vinyl triflates obtained were applied to the stereoselective synthesis of structurally diverse (Z)-allylic alcohols via transition metal-catalyzed cross-coupling reaction and [1,2]-Wittig rearrangement.

Discovery of novel 1-azoniabicyclo[2.2.2]octane muscarinic acetylcholine receptor antagonists

A novel 4-hydroxyl(diphenyl)methyl substituted quinuclidine series was discovered as a very promising class of muscarinic antagonists. The structure-activity relationships of the connectivity of the diphenyl moiety to the quinuclidine core and around the ring nitrogen side chain are described. Computational docking studies using an homology model of the M3 receptor readily explained the observed structure-activity relationship of the various compounds. Compound 14o was identified as a very potent, slowly reversible M3 antagonist with a very long in vivo duration of bronchoprotection.

Muscarinic acetylcholine receptor antagonists

Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.

Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B

Structure-based drug design of novel isoquinoline-5-sulfonamide inhibitors of PKB as potential antitumour agents was investigated. Constrained pyrrolidine analogues that mimicked the bound conformation of linear prototypes were identified and investigated by co-crystal structure determinations with the related protein PKA. Detailed variation in the binding modes between inhibitors with similar overall conformations was observed. Potent PKB inhibitors from this series inhibited GSK3β phosphorylation in cellular assays, consistent with inhibition of PKB kinase activity in cells.

A efficient method for the reductive cleavage of aromatic acetals with ZrCl4-LiAlH4

In our survey of the chemistry of ZrCl4-LiAlH4, we have found that acetals can be reduced to the corresponding ethers.We have explored the reductive condition and studied the reductive cleavage of different-membered cyclic acetals

REDUCTION OF ACETALS WITH CpTiCl3-LiAlH4

The reduction of cyclic acetals and ketals derived from aromatic or aliphatic aldehydes and ketones with CpTiCl3-LiAlH4 system in diethyl ether at 30 deg C affords the corresponding hydroxyethyl ethers and the corresponding alkyl benzene or aliphatic hydrocarbons.

On the surface-anesthetic activity of some ether alcohols (author's transl)

An account of the preparation and surface anesthetic potency of 12 ether alcohols of the type X-O-Y-OH is given in this paper. The anaesthetic intensity and effective duration of a chloronaphthalene derivative of this type lie within the range of action of cocain.