1200444-64-9

Basic information

• Product Name: N-(4-bromobenzyl)picolinamide
• Synonyms: N-(4-bromobenzyl)picolinamide
• CAS NO: 1200444-64-9
• Molecular Weight: 291.147
• Mol File: 1200444-64-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(4-bromobenzyl)picolinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-bromobenzyl)picolinamide(1200444-64-9)
• EPA Substance Registry System: N-(4-bromobenzyl)picolinamide(1200444-64-9)

Safety Data

• Hazardous Substances Data: 1200444-64-9(Hazardous Substances Data)

Upstream product

• 98-98-6 2-Picolinic acid 
• 3959-07-7 4-Bromobenzylamine 

Downstream Products

• 1200444-70-7 C₁₅H₁₃BrN₂O₃ 
• 675109-26-9 6-bromo-1-oxo-2,3-dihydro-1H-isoindole 
• 586-76-5 4-Bromobenzoic acid 

Relevant articles and documents

Cobalt-Catalyzed Selective Synthesis of Isoquinolines Using Picolinamide as a Traceless Directing Group

Picolinamide has first been employed as a traceless directing group for the cobalt-catalyzed oxidative annulation of benzylamides with alkynes to synthesize isoquinolines through C-H/N-H bonds activation. Oxygen is used as a terminal oxidant. This protocol exhibits good functional group tolerance and excellent regioselectivity. Both terminal and internal alkynes can be efficiently applied to this catalytic system as substrates.

[Cp*RhIII] in an Ionic Liquid as a Highly Efficient and Recyclable Catalytic Medium for Regio- and Diastereoselective Csp3–H Carbenoid Insertion

Reported herein is a bidentate-assisted Csp3–H bond insertion using Cp*RhIII/IL as a highly efficient and recyclable catalytic medium, while showing good functional group tolerance. Notably, the application of ionic liquid not only lowered the temperature, but also enhanced the diastereoselectivity of this reaction. This work significantly expanded the scope of ionic liquids in Csp3–H functionalizations.

Palladium-catalyzed aryl C-H bonds activation/acetoxylation utilizing a bidentate system

[Chemical Equation Presented] A palladium-catalyzed aryl C-H bonds activation/acetoxylation reaction utilizing a bidentate system has been explored. This transformation has been applied to a wide array of pyridine and 8-aminoquinoline derivatives and it exhibits excellent functional group tolerance.