1200461-34-2

Upstream product

• 61986-34-3 (R/S)-1-(2-nitrophenyl)-2,2-dimethyl-1-propanol 
• 630-19-3 pivalaldehyde 
• 609-73-4 o-nitroiodobenzene 
• 1200462-94-7 3',5‘-O-bis(tert-butylmethylsilyl)-5-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxyuridine 
• 1028383-90-5 N³-tert-butyloxycarbonyl-5-bromomethyl-3',5'-bis-O-tert-butyldimethylsilyl-2'-deoxyuridine 
• 1200463-02-0 (S)-1-(2-nitrophenyl)-2,2-dimethyl-1-propanol 
• 1200461-32-0 3’,5’-O-bis-(tert-butyldimethylsilyl)-5-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-4-O-(2,4,6-triisopropylbenzenesulfonyl)-2’-deoxyuridine 

Downstream Products

• 1200461-36-4 5-[(S)-1-(2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-2’-deoxycytidine 
• 1200463-25-7 5-[(S)-1-(2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-2'-deoxycytidine-5'-triphosphate 

Relevant academic research and scientific papers

Nucleotides and nucleosides and methods for their use in DNA sequencing

The present invention relates generally to labeled and unlabled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention relates in part to nucleotides and nucleosides with chemically cleavable, photocleavable, enzymatically cleavable, or non-photocleavable groups and methods for their use in DNA sequencing and its application in biomedical research.

5-METHOXY. 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING

The present invention relates generally to 3'-OH unblocked nucleotides and nucleosides labeled and unlabeled with 5-methoxy-substituted nitrobenzyl-based photocleavable terminating groups for use in methods and systems related to DNA and RNA sequencing an

Stereochemistry of benzylic carbon substitution coupled with ring modification of 2-nitrobenzyl groups as key determinants for fast-cleaving reversible terminators

A complete set of 2-nitrobenzyl-modified reversible terminators have been developed, which upon exposure to UV light generate natural hydroxymethyl nucleotides (see scheme). The combination of a stereospecific (S)-tert-butyl group (R) at the benzylic carb