1200536-07-7

Upstream product

• 98061-21-3 4-pyridin-2-yl-benzoic acid methyl ester 
• 68-12-2 N,N-dimethyl-formamide 
• 78-67-1 2,2'-azobis(isobutyronitrile) 
• 75-05-8 acetonitrile 
• 135205-66-2 N?cyanosuccinimide 
• 109-04-6 2-bromo-pyridine 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 21864-90-4 N-(tert-butyl)benzimidoyl cyanide 
• 7321-55-3 2,2-dimethylmalononitrile 

Relevant academic research and scientific papers

Rhodium(iii)-catalyzed aromatic C-H cyanation with dimethylmalononitrile as a cyanating agent

A rhodium-catalyzed aromatic C-H bond direct cyanation with safe, bench-stable, and commercially available dimethylmalononitrile as the cyanating agent has been successfully developed by using copper oxide as a promotor. Pyridine, quinoline, pyrimidine and pyrazole were used as the directing group in this type of C-H bond direct cyanation reaction.

α-Iminonitrile: A new cyanating agent for the palladium catalyzed C-H cyanation of arenes

An efficient palladium-catalyzed C-H cyanation reaction of arenes using α-iminonitrile as a new cyanating reagent has been developed. With high regioselectivity and broad substrate scope, this reaction offers monocyanated products in moderate to excellent

Cobalt-catalyzed C-H cyanation of arenes and heteroarenes

Carboxylate assistance proved to be the key for the success of efficient cobalt(III)-catalyzed C-H cyanations. Thus, an in situ generated cationic cobalt complex was identified as a versatile catalyst for the site-selective synthesis of various aromatic a

Cobalt-catalyzed C-H cyanation of (Hetero)arenes and 6-Arylpurines with N -cyanosuccinimide as a new cyanating agent

A cobalt-catalyzed C-H cyanation reaction of arenes has been developed using N-cyanosuccinimide as a new electrophilic cyanating agent. The reaction proceeds with high selectivity to afford monocyanated products with excellent functional group tolerance. Substrate scope was found to be broad enough to include a wide range of heterocycles including 6-arylpurines.

Copper-catalyzed aromatic C-H bond cyanation by C-CN bond cleavage of inert acetonitrile

Cut and paste! A Cu-catalyzed aromatic C-H cyanation with acetonitrile as the nitrile source by C-CN cleavage has been developed (see scheme; TMEDA=N,N,N′,N′-tetramethylethylenediamine). The reaction is catalytic in copper, and it is found that using (Me

Copper-mediated direct aryl C-H cyanation with azobisisobutyronitrile via a free-radical pathway

An unprecedented protocol for the copper-mediated direct cyanation of aryl C-H by employing 2,2′-azobisisobutyronitrile (AIBN) as a free radical "CN" source is presented. The protocol not only provides a more efficient pathway for the synthesis of aryl nitriles in terms of the yields and the loading amount of copper salts but also, more importantly, represents a novel strategy for aryl C-H cyanation via a CN free-radical mechanism as compared to the CN anion-participating protocols often reported.

A new combined source of "cN" from N, N -dimethylformamide and ammonia in the palladium-catalyzed cyanation of aryl C-H bonds

An unprecedented protocol for cyanation at arene C-H bonds has been developed by employing N,N-dimethylformamide and ammonia as a combined source for the cyano "CN" unit. Isotopic incorporation experiments revealed that the carbon and nitrogen of the "CN" originate from the N,N-dimethyl moiety of DMF and ammonia, respectively. The present cyanation reaction shows an excellent degree of regioselectivity, producing only monosubstituted nitriles at the less hindered C-H position, and it allows for the preparation of doubly labeled nitrile compounds for the first time.

Chelation-assisted palladium-catalyzed cascade bromination/cyanation reaction of 2-arylpyridine and 1-arylpyrazole C-H bonds

(Chemical Equation Presented) A chelation-assisted palladium-catalyzed cascade bromination/cyanation reaction of 2-arylpyridine and 1-arylpyrazole C-H bonds has been developed. Notably, the reaction employs K3[Fe(CN) 6] as a safe and