21864-90-4

Upstream product

• 119072-55-8 tert-butylisonitrile 
• 100-47-0 benzonitrile 
• 591-50-4 iodobenzene 
• 2179-92-2 tri-n-butyltin cyanide 
• 105488-73-1 2-phenyl-2-(tert-butyl(hydroxy)amino)acetonitrile 
• 74-88-4 methyl iodide 
• 60340-31-0 Ethylsulfanyl-phenyl-acetonitrile 
• 75-64-9 tert-butylamine 
• 3376-24-7 N-tert-butyl-α-phenylnitrone 
• 105488-71-9 N-tert-butyl-α-cyanobenzylhydroxylamine trimethylsilyl ether 

Downstream Products

• 79514-04-8 α-(N-tert-butylamino)phenylethylamine 
• 874-90-8 4-methoxybenzonitrile 
• 33488-29-8 2-amino-3-phenylquinoxaline 
• 767-00-0 4-cyanophenol 
• 35704-19-9 N-(4-cyanophenyl)acetamide 
• 623-03-0 4-Cyanochlorobenzene 
• 1443-80-7 4-cyanophenyl methyl ketone 
• 619-72-7 4-nitrobenzonitrile 
• 1210-12-4 9-cyanoanthracene 
• 613-46-7 2-naphthalenecarbonitrile 
• 2920-38-9 4-cyano-1,1'-biphenyl 
• 86-53-3 1-Cyanonaphthalene 
• 4210-32-6 4-tert-butyl benzonitrile 
• 4421-09-4 piperonylonitrile 

Relevant academic research and scientific papers

Palladium-Catalyzed Synthesis of Aryl Nitriles: Using α-Iminonitrile as Cyano Source for Aryl Halide Cyanations

An efficient and ligand-free palladium-catalyzed exchange reaction to synthesize aryl nitriles by using α-iminonitrile as a starting reagent has been developed. This methodology provides an optional method for the synthesis of aryl nitriles with moderate to good yields. At the same time, this approach is adaptable for many substrates.

Palladium-Catalyzed Synthesis of α-Iminonitriles from Aryl Halides via Isocyanide Double Insertion Reaction

An efficient one-pot synthesis of α-iminonitriles from readily available aryl halides via palladium-catalyzed double isocyanide insertion and elimination has been developed, without using various hypertoxic cyanides and excess oxidants. Furthermore, the utility of this reaction was demonstrated by the rapid total synthesis of quinoxaline and the reaction of functional groups exchanged with aryl halides. (Chemical Equation Presented).

Cyano-O-silylhydroxylamines as Nitrone Blocking Groups

Addition of trimethylsilyl cyanide to N-alkyl-C-phenylnitrones affords cyano-O-silylhydroxylamines; reaction of these species with silver fluoride regenerates the nitrone in quantitative yield thereby providing a useful nitrone blocking group.

Palladium Catalyzed Iminocarbonylation of Bromobenzene with Isocyanide and Organotin Compounds

Palladium catalyzed reactions of ternary systems involving bromobenzene, t-butyl isocyanide, and organotin compounds were found to occur giving the corresponding imines, although the catalytic efficiencies were rather low.

Une nouvelle methode de transformation des aldehydes aromatiques en α-iminonitriles Ar-C(CN)=N-R

The reaction with amines of bromoderivates Ar-CBr(SEt)-CN, easily obtained in high yields from aldehydes, provides a convinient route to C-aryl N-alkyl (or aryl) α-iminonitriles.