1201-90-7

Usage

Uses

Used in Organic Synthesis:
Ethyl 4-chloromethylbenzoate is used as a synthetic intermediate for the production of various chemical substances. Its unique structure allows it to be a valuable component in the synthesis of a wide range of compounds, contributing to the development of new materials and products in the chemical industry.
Used in Chemical Production:
Ethyl 4-chloromethylbenzoate is used as a key component in the manufacturing process of certain chemicals. Its presence in the synthesis process can lead to the creation of new compounds with specific properties, making it an essential part of the chemical production workflow.
Safety and Storage:
Due to limited information available on the potential hazards or safety concerns associated with Ethyl 4-chloromethylbenzoate, it is recommended to handle Ethyl 4-chloromethylbenzoate with the usual precautions for dealing with chemicals. It should be stored in a cool and ventilated area, away from sources of heat or ignition, to minimize the risk of accidents or adverse reactions.

InChI:InChI=1/C10H11ClO2/c1-2-13-10(12)9-5-3-8(7-11)4-6-9/h3-6H,2,7H2,1H3

Upstream product

• 64-17-5 ethanol 
• 876-08-4 p-(chloromethyl)benzoyl chloride 
• 1642-81-5 p-(chloromethyl)benzoic acid 
• 94-08-6 4-methylbenzoic acid ethyl ester 
• 103440-03-5 3-nitro-(4-chloromethyl) benzoic acid 
• 99-94-5 p-Toluic acid 
• 3006-96-0 3-hydroxymethyl-benzoic acid 
• 15852-63-8 ethyl 4-(hydroxymethyl)benzoate 

Downstream Products

• 78329-94-9 4-[(2-diethylamino-ethoxy)-methyl]-benzoic acid ethyl ester 
• 860257-69-8 2-(4-ethoxycarbonyl-benzyl)-acetoacetic acid ethyl ester 
• 57624-33-6 ethyl 4-(mercaptomethyl)benzoate 
• 94757-47-8 4,4'-(2-thia-propanediyl)-di-benzoic acid diethyl ester 
• 128982-36-5 ethyl 4-[(diethylamino)methyl]benzoate 
• 1906-91-8 4-<3-Chlor-4-propionyl-phenoxymethyl>-benzoesaeure-aethylester 
• 1164-19-8 4-<3-Chlor-4-butyryl-phenoxymethyl>-benzoesaeure 
• 138591-62-5 4-[(Methyl-prop-2-ynyl-amino)-methyl]-benzoic acid ethyl ester 
• 148952-69-6 2-((4'-carbethoxyphenyl)methyl)cyclopentanone 
• 90072-39-2 4-(2,5-Diamino-6-methyl-pyrimidin-4-ylsulfanylmethyl)-benzoic acid ethyl ester 
• 94-08-6 4-methylbenzoic acid ethyl ester 
• 150713-16-9 Ethyl 4-(chloromethyl)-3-nitrobenzoate 
• 84439-82-7 5-amino-6-(p-ethoxycarbonylphenylmethyl)mercapto-4-methoxypyrimidine 

Relevant academic research and scientific papers

1,3-dipolar compound bearing an imidazole functional group

In a 1,3-dipolar compound of formula Q-A-B, Q comprises a dipole containing at least and preferably one nitrogen atom, A, which is preferably divalent, is an atom or a group of atoms connecting Q to B, and B comprises an imidazole ring. An unsaturated polymer modified by grafting the 1,3-dipolar compound is also disclosed.

ORGANIC NANOFIBER STRUCTURE BASED ON SELF-ASSEMBLED ORGANOGEL, ORGANIC NANOFIBER TRANSISTOR USING THE SAME, AND METHOD OF MANUFACTURING THE ORGANIC NANOFIBER TRANSISTOR

An organic nanofiber including a gelled organic semiconductor compound. Also disclosed is an organic semiconductor transistor and a method of manufacturing an organic semiconductor transistor.

Large-scale preparation of polyfunctional benzylic zinc reagents by direct insertion of zinc dust into benzylic chlorides in the presence of lithium chloride

Highly functionalized benzylic zinc chlorides are prepared by the direct insertion of commercially available zinc dust into the corresponding benzylic chlorides in the presence of stoichiometric amount of lithium chloride. These polyfunctional zinc organometallics react with various electrophiles leading to a broad range of functionalized products. Georg Thieme Verlag Stuttgart.

High-performance organic semiconductors for thin-film transistors based on 2,7-divinyl[1]benzothieno[3,2-b]benzothiophene

We have synthesized two novel organic semiconductors, which have a symmetrically substituted 2,7-divinyl[1]benzothieno[3,2-b]benzothiophene backbone. They show good electrical performances on a SiO2/Si substrate, with high field-effect mobiliti

Indium-catalyzed direct chlorination of alcohols using chlorodimethylsilane-benzil as a selective and mild system

The InCl3-catalyzed reaction of alcohols with chlorodimethylsilane (HSiMe2Cl) in the presence of benzil gave the corresponding organic chlorides under mild conditions. Benzil significantly changes the reaction course because the reducing product through dehydroxyhydration was obtained in the absence of benzil. The secondary or tertiary alcohols were effectively chlorinated. The substrates bearing acid-sensitive functional groups were also applied to this system. The highly selective chlorination of the tertiary site was observed in the competitive reaction between tertiary and primary alcohols. The highly coordinated hydrosilane generated from benzil and HSiMe2Cl is an important intermediate. Copyright

Kinetics of the reaction of sodium arylthiolates with nitro-carboxybenzyl halide derivatives

The rate constants for the reactions of 4-halomethyl-3-nitrobenzoic acids, the nonnitro derivatives, and their ethyl esters with arylthiolates were measured at different temperatures. It was found that the retardation in rate constants compared to benzyl halides is due to the electrostatic repulsion between the electronegative substituents (COO- and/or NO2) in the substrates and thiolate ions Good correlations between log K2 values of the acids and carbon basicities of thiolates were found while log k2 values of the esters show good straight lines with Hammett a constants, pKa. and carbon basicities of arylthiolates.

ALKALINE C-S BOND CLEAVAGE OF SOME ARYLTHIOMETHYL BENZOATES

Methyl and ethyl--3-nitrobenzoates and the corresponding non-nitro derivatives have been synthesized and their structures proven.The action of 5percent sodium hydroxide solution on these esters gave the corresponding diaryl disulfides besides 3-nitro-4-methylbenzoic acid or 4-methylbenzoic acid. Key words: Arylthiomethyl benzoates; C-S bond fission and mass spectra.

Synthesis and Properties of Diethyl 5,10-Dihetera-5,10-dihydroindenoindene-2,7-dicarboxylates

A series of six heterocyclic diesters 1b-6b containing all combinations of nitrogen, sulfur, and selenium has been prepared from a common precursor, diethyl 2,2'-dinitrostilbene-4,4'-dicarboxylate.Electrochemical analysis showed oxidation potential increases in the order NA liquid crystals.A new synthetic method leading to the indoloindazole ring system has been found.

Synthesis, biological evaluation and quantitative structure activity relationship analysis of nuclearsubstituted pargylines as competitive inhibitors of MAO-A and MAO-B

A series of nuclear substituted derivatives of pargyline has been prepared and tested (under controlled conditions designed to measure the competitive component of the inhibition) as competitive inhibitors of MAO-A and -B. Adequate correlation of the biological data with the physicochemical constants of substituent groups was obtained only when the m- and p-substituted derivatives were considered separately. Due to the narrow range of activity displayed by the p-substituted derivates when inhibiting MAO-B, meaningful correlations were not found. However, the inhibition of MAO-B by the m-substituted derivatives required the inclusion of the Verloop L parameter for adequate correlation suggesting that the inhibitor binding site of MAO-B is present within a cavity of more limited lateral dimensions than that present on the MAO-A surface. Inhibition of both MAO-A and -B demonstrated a parabolic relationship between inhibitory activity and Π. Whereas this parabolic relationship showed a maximal value for inhibition of MAO-A (mean Π0 = 0.86), inhibition of MAO-B demonstrated a minimal value of Π(Π(min) = -0.5)i.e.the optimal value of Π for inhibition of MAO-B has not been achieved for this series of compounds but such would be greater than that demonstrated for MAO-A. The Hammett σ function was important or significant only in the inhibition of MAO-A by the p-substituted derivatives.