15852-63-8

Basic information

• Product Name: Benzoic acid, 4-(hydroxymethyl)-, ethyl ester
• Synonyms: 4-Hydroxymethyl-benzoesaeure-aethylester;4-hydroxymethyl-benzoic acid ethyl ester
• CAS NO: 15852-63-8
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Mol File: 15852-63-8.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-(hydroxymethyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(hydroxymethyl)-, ethyl ester(15852-63-8)
• EPA Substance Registry System: Benzoic acid, 4-(hydroxymethyl)-, ethyl ester(15852-63-8)

Safety Data

• Hazardous Substances Data: 15852-63-8(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 3006-96-0 3-hydroxymethyl-benzoic acid 
• 85719-68-2 4-[(Diisopropoxy-methyl-silanyl)-methyl]-benzoic acid ethyl ester 
• 6287-86-1 p-ethoxycarbonylbenzaldehyde 
• 60-29-7 diethyl ether 
• 201230-82-2 carbon monoxide 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 59016-93-2 p-hydroxymethylphenylboronic acid 
• 1609-47-8 diethyl dicarbonate 
• 636-09-9 diethyl terephthalate 
• 100-21-0 terephthalic acid 
• 50-00-0 formaldehyd 
• 4334-88-7 p-ethoxycarbonylphenylboronic acid 
• 619-66-9 4-Carboxybenzaldehyde 

Downstream Products

• 516469-48-0 4-(4-nitro-benzoyloxymethyl)-benzoic acid ethyl ester 
• 108836-42-6 ethyl 4-<(oxiranylmethoxy)methyl>benzoate 
• 213547-83-2 4-Vinyloxymethyl-benzoic acid ethyl ester 
• 1439362-40-9 ethyl 4-((diisopropoxyphosphoryl)(hydroxy)methyl)benzoate 
• 869297-03-0 ethyl 5-{[({4-[(ethyloxy)carbonyl]phenyl}methyl)oxy]methyl}-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate 
• 7153-22-2 ethyl 4-cyanobenzoate 
• 108836-65-3 C₂₆H₃₀N₂O₆ 
• 108836-45-9 4-[3-Imidazol-1-yl-2-(4-methoxy-benzyloxy)-propoxymethyl]-benzoic acid ethyl ester 
• 108836-44-8 ethyl 4-<<2-hydroxy-3-(1-H-imidazol-1-yl)propoxy>methyl>benzoate 
• 6287-86-1 p-ethoxycarbonylbenzaldehyde 

Relevant articles and documents

Iron-catalyzed chemoselective hydride transfer reactions

A Diaminocyclopentadienone iron tricarbonyl complex has been applied in chemoselective hydrogen transfer reductions. This bifunctional iron complex demonstrated a broad applicability in mild conditions in various reactions, such as reduction of aldehydes over ketones, reductive alkylation of various functionalized amines with functionalized aldehydes and reduction of α,β-unsaturated ketones into the corresponding saturated ketones. A broad range of functionalized substrates has been isolated in excellent yields with this practical procedure.

Bulky N-Heterocyclic-Carbene-Coordinated Palladium Catalysts for 1,2-Addition of Arylboron Compounds to Carbonyl Compounds

The synthesis of primary, secondary, and tertiary alcohols by the 1,2-addition of arylboronic acids or boronates to carbonyl compounds, including unactivated ketones, using novel bulky yet flexible N-heterocyclic carbene (NHC)-coordinated 2,6-di(pentan-3-yl)aniline (IPent)-based cyclometallated palladium complexes (CYPs) as catalysts is reported. The PhS-IPent-CYP-catalyzed reactions are efficient at low catalyst loadings (0.02–0.3 mol% Pd), and the exceptional catalytic activity for 1,2-addition is attributed to the steric bulk of the NHC ligand. These reactions can yield a wide range of functionalized benzylic alcohols that are difficult to synthesize by classical protocols using highly active organomagnesium or lithium reagents.

Palladium-catalyzed hydroxymethylation of aryl-and heteroarylboronic acids using aqueous formaldehyde

Cyclometallated NHC palladium complexes prepared from palladium(II) acetate [Pd(OAc)2] and unsymmetrical 1,3-diarylimidazolinium salts catalyzed the hydroxymethylation of (hetero)arylboronic acids using an excess amount of formalin to afford (hetero)arylm