120113-87-3Relevant articles and documents
New synthesis of a pyrroloquinoline skeleton, the martinelline core, using a tandem Michael-aldol strategy
Hara, Osamu,Sugimoto, Kazuhiko,Makino, Kazuishi,Hamada, Yasumasa
, p. 1625 - 1627 (2007/10/03)
The pyrroloquinoline moiety of Martinelline, a naturally occurring bradykinin receptor antagonist, has been synthesized from 1,2-dihydroquinoline which was prepared by using a tandem Michael-aldol reaction as a key step.
Cobalt-Mediated Intermolecular Radical Additions to Carbon-to-Carbon Double Bonds leading to New Functionalised Alkenes
Bhandal, Harcharan,Howell, Amy R.,Patel, Vinod F.,Pattenden, Gerald
, p. 2709 - 2714 (2007/10/02)
Alkyl radicals generated by photolytic homolysis of cobalt salophen reagents, e.g. (6) and (15), are shown to add to activated carbon-to-carbon double bonds, i.e. ethyl acrylate, methyl vinyl ketone, acrylonitrile, and styrene, producing preparatively useful yields of new alkene products, viz. (9), (10), (12) and (14) , and (16) .The reactions proceed via radical (Michael) additions, followed by 'dehydrocobaltation' from the presumed organocobalt intermediates (2) (Scheme 4).By use of this chemistry, in combination with the Schrauzer 'hydrocobaltation' reaction of alkenes, a new method for the cross-coupling reactions between two alkenes, leading to new functionalised alkenes, e.g. (24), (25), (26), (27), (28), and (29), is developed .
