1201187-46-3

Basic information

• Product Name: 2-amino-5-(p-toluenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine
• Synonyms: 2-amino-5-(p-toluenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine
• CAS NO: 1201187-46-3
• Molecular Weight: 288.33
• Mol File: 1201187-46-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-amino-5-(p-toluenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-(p-toluenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine(1201187-46-3)
• EPA Substance Registry System: 2-amino-5-(p-toluenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine(1201187-46-3)

Safety Data

• Hazardous Substances Data: 1201187-46-3(Hazardous Substances Data)

Usage

Uses

5-[(4-Methylphenyl)sulfonyl]-5H-Pyrrolo[2,3-b]pyrazin-2-amine functions as a reagent in the ligand-controlled and iridium-catalyzed preparation of imidazo[1,2-a]pyrrolo[2,3-e]pyrazines or β-keto amines via reaction of sulfoxonium ylides with 2-amino heterocycles.

Upstream product

• 875781-43-4 2-bromo-5H-pyrrolo[2,3-b]pyrazine 
• 98-59-9 p-toluenesulfonyl chloride 
• 1201187-44-1 N-(5-(p-toluenesulfonyl)pyrrolo[2,3-b]pyrazin-2-yl)carbamic acid tert-butyl ester 
• 1201186-54-0 2-bromo-5-(p-toluenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine 
• 875781-41-2 5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine 

Downstream Products

• 1310726-60-3 (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide 

Relevant articles and documents

Development of a Scalable Enantioselective Synthesis of JAK Inhibitor Upadacitinib

Process development of a six-stage synthesis of upadacitinib, a JAK1 inhibitor, is described. It is highlighted by an enantioselective and diastereoselective hydrogenation of a tetrasubstituted olefin to set the two pyrrolidine stereocenters. Preparation of the main fragments and strategies to link them together, optimization of the imidazole cyclization, and in-depth understanding of the formation of the urea moiety at the final stage are discussed.

Preparing method of (5-tosyl-5H-pyrrolo[2,3-b]pyrazine-2-yl)methyl carbamate

The invention relates to a preparing method of (5-tosyl-5H-pyrrolo[2,3-b]pyrazine-2-yl)methyl carbamate. In the method, 5-bromo-4,7-diazindole serves as the initial raw material, and (5-tosyl-5H-pyrrolo[2,3-b]pyrazine-2-yl)methyl carbamate is prepared thr

Influenza virus replication inhibitors and uses thereof (by machine translation)

The invention provides a compound as an influenza virus replication inhibitor, a method for preparing the same, a pharmaceutical composition containing the compound and application. (by machine translation)