120130-29-2

Upstream product

• 1013-88-3 Benzophenone imine 
• 130156-97-7 amino acetic acid (1S, 2R, 5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester hydrochloride 
• 122449-89-2 (-)-(1S,2R,5S)-1-Chloroacetoxy-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexane 
• 65253-04-5 (-)-8-phenylmenthol 
• 136059-92-2 N-(diphenylmethylene)glycinate 
• 69555-14-2 ethyl N-diphenylmethylene glycine 
• 71804-27-8 (1R,2S,5R)-(+)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl chloroacetate 
• 119-61-9 benzophenone 
• 120130-28-1 (-)-8-phenylmenthan-3-yl glycinate 
• 120130-28-1 (-)-8-phenylmenthyl glycinate 

Downstream Products

• 95716-07-7 L-<β-11C>phenylalanine 
• 169266-13-1 D-<β-11C>phenylalanine 
• 130157-02-7 (S)-2-(Benzhydrylidene-amino)-pent-4-enoic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 130157-02-7 (R)-2-(Benzhydrylidene-amino)-pent-4-enoic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 

Relevant academic research and scientific papers

Method for synthesizing N-Boc-L-propargyl glycine

The invention provides a method for synthesizing N-Boc-L-propargyl glycine. According to the synthetic method, N-glycine ethyl ester serves as an initial raw material, and a target compound is synthesized through a three-step reaction. In the product preparation process, chiral synthesis is performed in the second step by adopting a chiral reagent, and the ee value of the product is increased. In the final step, a 'one-pot' process is adopted, the purification and treatment process of the intermediate link is reduced, the process operation is simplified, the solvent usage amount and the sewage discharge amount are reduced, the production cost is reduced, energy conservation and consumption reduction are realized, and the influence on the environment is alleviated. According to the product prepared by the process, the total yield is more than 70%, the purity detected by HPLC (High Performance Liquid Chromatography) is more than 99%, and the ee value is more than 98%. The method disclosed by the invention is easy to operate, high in yield and high in purity and is favorable for large-scale industrial production.

Double asymmetric synthesis: Palladium chiral complexes in the alkylation of chiral schiff bases derived from glycine

A new double asymmetric induction in carbon-carbon bond formation is achieved by the use of palladium chiral complexes in the alkylation of chiral Schiff bases 1 derived from glycine. High diastereoisomeric excesses are obtained (90-99%) using N,N-cyclohe

Asymmetric Synthesis of L-Alanine and L-Phenylalanine by a Phase-Transfer Alkylation Reaction

The asymmetric syntheses of enantiomerically enriched L-alanine and L-phenylalanine t1/2 20.4 min for 11C) by phase-transfer alkylation of (-)-8-phenylmenthan-3-yl N-(diphenylmethylene)-glycenate with methyl and benzyl iodides, respectively, are presented.The total synthesis times were 35-55 min, from the start of synthesis of the methyl and (α-11C>benzyl iodides.The products were obtained in 15-40percent (decay corrected) radiochemical yields and higher than 98percent radiochemical purities.The enantiomeric purities of the amino acids were determined to be 52-55percent enantiomeric excess (e.e).In a typical run 600 MBq of L-alanine was obtained, starting with 5.2 GBq of carbon dioxide.