130156-97-7

Upstream product

• 122449-89-2 (-)-(1S,2R,5S)-1-Chloroacetoxy-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexane 
• 57707-91-2 (1S,2R,5S)-8-(+)-phenylmenthol 
• 120130-28-1 (-)-8-phenylmenthyl glycinate 

Downstream Products

• 130157-02-7 (R)-2-(Benzhydrylidene-amino)-pent-4-enoic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 130157-02-7 (S)-2-(Benzhydrylidene-amino)-pent-4-enoic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 120130-29-2 (Benzhydrylidene-amino)-acetic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 

Relevant academic research and scientific papers

SYTHESIS OF RENIN INHIBITORS INVOLVING A CYCLOADDITION REACTION

The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula (III), wherein R, R1, and R' are as defined in the specification, or a salt thereof, and a compound of formula (IV) wherein R, R1, R2 and R' are as defined in the specification, and processes of manufacturing these.

Double asymmetric synthesis: Palladium chiral complexes in the alkylation of chiral schiff bases derived from glycine

A new double asymmetric induction in carbon-carbon bond formation is achieved by the use of palladium chiral complexes in the alkylation of chiral Schiff bases 1 derived from glycine. High diastereoisomeric excesses are obtained (90-99%) using N,N-cyclohe