1201359-25-2

Upstream product

• 1201359-60-5 (1'S,3R,4R)-4-acetoxy-3-(1'-trimethylsilyloxy-2',2',2'-trifluoroethyl)-1-(trimethylsilyl)-2-azetidinone 
• 173459-91-1 (S)-6-methoxy-1-(trimethylsilyloxy)cyclohex-1-ene 
• 1201359-63-8 (1'S,3R,4R)-4-acetoxy-3-(1'-trimethylsilyloxy-2',2',2'-trifluoroethyl)-2-azetidinone 

Downstream Products

• 1201359-28-5 (3S,4R)-1-allyloxalyl-4-[(1R,3S)-3-methoxy-2-oxo-cyclohexyl]-3-[1-(S)-trimethylsilyloxy-2,2,2-trifluoroethyl]-2-azetidinone 

Relevant academic research and scientific papers

Stereoselective synthesis of fluorine-containing analogues of anti-bacterial sanfetrinem and LK-157

The synthesis of (1′S,3R,4R)-4-acetoxy-3-(1′-trimethylsilyloxy-2′,2′,2′-trifluoroethyl)-2-azetidinone (10) precursor of modified carbapenems is described relying upon [Ru(C6Me6)(S,S)-(CH2)5NSO2DPEN]-catalyzed asymmetric transfer hydrogenation under dynamic kinetic resolution using HCO2H-Et3N. This fluorine-containing precursor yielded the targeted trinems 1 and 2 via a stereoselective key step condensation with lithium (S)-6-methoxy-cyclohexenolate.

New trinem antibiotics and inhibitors of beta-lactamases

The present invention relates to a compound of formula (I) in particular compounds of formula (Ia), the use of a therapeutically effective amount of one or more compounds of formula (I) or (Ia) as a broad-spectrum antibiotic and the use of a pharmaceutica