173459-91-1

Basic information

• Product Name: Silane, [[(6S)-6-methoxy-1-cyclohexen-1-yl]oxy]trimethyl-
• CAS NO: 173459-91-1
• Molecular Formula: C10H20O2Si
• Molecular Weight: 200.353
• Mol File: 173459-91-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Silane, [[(6S)-6-methoxy-1-cyclohexen-1-yl]oxy]trimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, [[(6S)-6-methoxy-1-cyclohexen-1-yl]oxy]trimethyl-(173459-91-1)
• EPA Substance Registry System: Silane, [[(6S)-6-methoxy-1-cyclohexen-1-yl]oxy]trimethyl-(173459-91-1)

Safety Data

• Hazardous Substances Data: 173459-91-1(Hazardous Substances Data)

Upstream product

• 4071-88-9 trimethylsilanyl-acetic acid ethyl ester 
• 155320-76-6 (2S)-2-methoxycyclohexanone 
• 75-77-4 chloro-trimethyl-silane 
• 677-22-5 tert-butylmagnesium chloride 
• 121961-00-0 Acetic acid (1S,2S)-2-methoxy-cyclohexyl ester 
• 134108-92-2 (1S,2S)-2-methoxycyclohexanol 
• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 134070-87-4 trans-2-methoxycyclohexyl butanoate 
• 134108-78-4 Butyric acid (1S,2S)-2-methoxy-cyclohexyl ester 
• 60624-22-8 (+/-)-trans-1-acetoxy-2-methyoxycyclohexane 
• 7429-40-5 trans-2-methoxycyclohexanol 

Downstream Products

• 1201359-25-2 (3S,4R)-4-[(1R,3S)-3-methoxy-2-oxo-cyclohexyl]-3-[1-(S)-trimethylsilyloxy-2,2,2-trifluoroethyl]-2-azetidinone 
• 1201359-73-0 (3S,4R)-3-[(1S)-2-Fluoro-1-trimethylsilyloxy-ethyl]-4-[(1R,3S)-3-methoxy-2-oxo-cyclohexyl]-2-azetidinone 

Relevant articles and documents

Stereoselective synthesis of fluorine-containing analogues of anti-bacterial sanfetrinem and LK-157

The synthesis of (1′S,3R,4R)-4-acetoxy-3-(1′-trimethylsilyloxy-2′,2′,2′-trifluoroethyl)-2-azetidinone (10) precursor of modified carbapenems is described relying upon [Ru(C6Me6)(S,S)-(CH2)5NSO2DPEN]-catalyzed asymmetric transfer hydrogenation under dynamic kinetic resolution using HCO2H-Et3N. This fluorine-containing precursor yielded the targeted trinems 1 and 2 via a stereoselective key step condensation with lithium (S)-6-methoxy-cyclohexenolate.

Diastereoselective synthesis of a key intermediate for the preparation of tricyclic β-lactam antibiotics

Asymmetric synthesis of (S)-5 has been accomplished with an excellent enantiomeric excess by hydrogenation of racemic 5 using ruthenium-BINAP- diamine-KOH system, followed by oxidation. Magnesium enolate of (2S)-2- methoxycyclohexanone [(S)-5] reacts with

The stereoselective synthesis of a key intermediate of the trinem antibiotic Sanfetrinem

By modulating the reactivity of the Lewis acid promoter it was possible to obtain, in a single stereoselective condensation step, the methoxyketone 7, an advanced intermediate in the synthesis of Sanfetrinem GV 104326.