1201566-89-3Relevant academic research and scientific papers
Synthesis and biological evaluation of N-substituted benzo[c] phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents
Genès, Constance,Lenglet, Ga?lle,Depauw, Sabine,Nhili, Raja,Prado, Soizic,David-Cordonnier, Marie-Hélène,Michel, Sylvie,Tillequin, Fran?ois,Porée, Fran?ois-Hugues
, p. 2117 - 2131 (2011/06/21)
Benzo[c]phenanthrolines and benzo[c]phenanthrolinones substituted by dialkylaminoalkyl side chains at position N5 and C6, respectively, were synthesised and their biological activity evaluated. They displayed interessant cytotoxicity associated with some DNA interactions. However, the low topoisomerase 1 affinity suggests that other cellular targets are responsible for the antiproliferative activity.
Synthesis of N-substituted benzo[c][1,7]- and benzo[c][1,8] phenanthrolin-(5H)-6-ones through a Pd-mediated Suzuki-Miyaura heteroaryl-aryl coupling reaction
Genès, Constance,Michel, Sylvie,Tillequin, Fran?ois,Porée, Fran?ois-Hugues
experimental part, p. 10009 - 10015 (2010/02/27)
In the course of the search for non-camptothecin topoisomerase I inhibitors we have undertaken the synthesis of N-substituted benzo[c][1,7]- and benzo[c][1,8]phenanthrolinone derivatives. An intermolecular Suzuki-Miyaura heteroaryl-aryl coupling reaction was planned as the key step. Then a nitro reduction followed by a concomitant lactamization achieved the construction of the tetracycle structures. This methodology permitted a rapid and efficient elaboration of biologically potent compounds.
