1201792-39-3Relevant academic research and scientific papers
Diastereoselective alkylation of glycinates by assistance of intramolecular potassium-fluorine interactions
Yamazaki, Takashi,Kawashita, Seiji,Kitazume, Tomoya,Kubota, Toshio
supporting information; experimental part, p. 11461 - 11464 (2010/04/24)
A study was conducted to demonstrate diatereoselective alkylation of glycinates by assistance of intermolecular potassium-fluorine interactions. Preparation of the starting materials for the investigations was carried out from the readily available fluorinated acetophenones. The investigations focused on finding appropriate alkylation conditions after their transformation to the corresponding enolates. The representative starting material was subjected to a solution of a base in THF at -78°C to generate the enolate. The model electrophile, BnBr was introduced in the investigations after stirring for 0.5 hours at the same temperature.
