1201798-95-9

Upstream product

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 62581-82-2 1-[3-(chloromethyl)-4-methoxyphenyl]-1-ethanone 
• 5815-08-7 tert-Butoxybis(dimethylamino)methane 
• 1201798-94-8 5-acetyl-2-methoxybenzyl pivalate 

Downstream Products

• 1201798-96-0 5-(2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-7-yl)-2-methoxybenzyl pivalate 
• 1201798-97-1 5-(2,4-dichloropyrido[2,3-d]pyrimidin-7-yl)-2-methoxybenzyl pivalate 

Relevant academic research and scientific papers

Pyridopyrimidine Or Pyrimidopyrimidine Compound, Prepration Method, Pharmaceutical Composition, And Use Thereof

The present invention belongs to the field of pharmaceutical Chemistry. In particular, the present invention relates to a pyridopyrimidine or pyrimidopyrimidine compound as represented by general formula (I), or an isomer thereof or a pharmaceutically acceptable salt, ester, prodrug or solvate thereof, a preparation method, a pharmaceutical composition and uses thereof in preparing a mTOR inhibitor. As a mTOR inhibitor, the compound or the pharmaceutical composition thereof can be used for treating a disease or condition due to PI3K-AKT-mTOR signalling pathway malfunction.

COMPOSITION AND PROCESS - 356

There is provided a process for the preparation of a compound of Formula 1, the use of said process in the preparation of a compound of Formula 5 or a phosphate, sulphate, hydrogensulphate, malate, citrate, tartrate or fumarate salt thereof, and the use of the fumarate salt in a composition for use in therapy.