1201913-76-9Relevant academic research and scientific papers
The regioselective bromine-lithium exchange reaction of alkoxymethyldibromobenzene: A new strategy for the synthesis of tofogliflozin as a SGLT2 inhibitor for the treatment of diabetes
Murakata, Masatoshi,Ikeda, Takuma,Kimura, Nobuaki,Kawase, Akira,Nagase, Masahiro,Kimura, Masahiro,Maeda, Kenji,Honma, Akie,Shimizu, Hitoshi
, p. 655 - 660 (2017/01/16)
The regioselective bromine-lithium exchange reaction of 2,4-dibromo-1-(1-methoxy-1-methylethoxymethyl)benzene (2), which resulted in optimized selectivity of 220:1, is described. Applying this method to the synthesis of tofogliflozin (1) as a SGLT2 inhibi
CRYSTAL OF SPIROKETAL DERIVATIVE, AND PROCESS FOR PRODUCTION THEREOF
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Page/Page column 29, (2011/04/25)
The present invention provides a process for preparing a spiroketal derivative, via an intermediate represented by Formula (VI): wherein variable groups and numbers are as defined in the specification, which can be produced from dihalobenzene derivatives in one pot reaction.
