1202166-87-7

Upstream product

• 332902-04-2 N-butylidene-4-methylbenzenesulfonamide 
• 1907-65-9 N-butyl-4-toluenesulfonamide 
• 7677-24-9 trimethylsilyl cyanide 
• 113845-15-1 N-butyl-N-fluoro-4-methylbenzenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 10442-39-4 tetra-n-butylammonium cyanide 

Relevant academic research and scientific papers

Direct Synthesis of α-Amino Nitriles from Sulfonamides via Base-Mediated C-H Cyanation

Herein, we disclose a transition-metal-free reaction system that enables α-cyanation of sulfonamides through C-H bond cleavage for the preparation of α-amino nitriles, including difficult-to-access all-alkyl α-tertiary scaffolds. More than 50 substrate examples prove a wide functional group tolerance. Additionally, its synthetic practicality is highlighted by gram-scalability and the late-stage modification of natural compounds. Mechanistic experiments suggest that this process involves in situ formation of an imine intermediate via base-promoted elimination of HF.

Transition-Metal-Free α Csp3?H Cyanation of Sulfonamides

This report describes the site-selective α-functionalization of sulfonylamide derivatives through the in-situ generation of imine intermediates. The N?F sulfonylamides, which could facilitate the elimination to generate imines, are coupled with TBACN to e

Amberlyst-15 catalysed synthesis of N-tosyl-α-aminonitriles through Strecker reaction

N-Tosyl-α-aminonitriles have been synthesised by a Strecker reaction of various N-tosyl aldimines with trimethylsilyl cyanide in the presence of catalytic amount of Amberlyst-15 polymer at room temperature under heterogeneous conditions.

Synthesis of α-aminonitriles through Strecker reaction of N-tosylaldimines using molecular iodine

The Strecker reaction of N-tosylaldimines with trimethylsilyl cyanide in the presence of catalytic amount of iodine at room, temperature produces the corresponding protected α-aminonitriles in high yields.