1202243-49-9Relevant academic research and scientific papers
Lewis base-catalyzed three-component Strecker reaction on water. An efficient manifold for the direct α-cyanoamination of ketones and aldehydes
Cruz-Acosta, Fabio,Santos-Exposito, Alicia,De Armas, Pedro,Garcia-Tellado, Fernando
, p. 6839 - 6841 (2009)
The first three-component organocatalyzed Strecker reaction operating on water has been developed. The manifold utilizes ketones (aldehydes) as the starting carbonyl component, aniline as the primary amine, acetyl cyanide as the cyanide source and N,N-dim
Highly efficient and convenient Strecker reaction of carbonyl compounds and amines with TMSCN catalyzed by MCM-41 anchored sulfonic acid as a recoverable catalyst
Dekamin, Mohammad G.,Mokhtari, Zahra
experimental part, p. 922 - 930 (2012/02/01)
MCM-41 anchored sulfonic acid (MCM-41-SO3H) was found to be a highly efficient and recoverable heterogeneous catalyst for the three-component Strecker reaction of aldehydes or ketones and diverse amines using trimethylsilyl cyanide (TMSCN) to afford the corresponding α-amino nitriles under mild conditions in high to quantitative yields. The simple experimental procedure along with easy recovery and reusability of the catalyst has led to development of a clean and environmentally friendly approach for the synthesis of α-amino nitriles.
Solvent-free three component Strecker reaction of ketones using highly recyclable and hydrophobic sulfonic acid based nanoreactors
Karimi, Babak,Zareyee, Daryoush
supporting information; experimental part, p. 8665 - 8670 (2010/07/15)
An efficient and environmentally benign system was developed for the one-pot three-component Strecker reaction of ketones under solvent-free conditions, with the use of a highly recoverable SBA-15 supported sulfonic acid. Also findings concerning the effects of functionalized inert groups and silica backbone pore size on substrate scope, catalytic activity and recycling behavior of the catalysts were briefly discussed. The simple experimental and product isolation procedure accompanied by easy recovery and reusability of the catalyst could be considered as attractive features of this new protocol which will hopefully develop a clean strategy for the synthesis of α-amino nitriles. The Royal Society of Chemistry 2009.
