120225-53-8

Usage

Uses

Used in Pharmaceutical Industry:
(2S,3S,4R,5R)-5-[6-amino-2-(phenethylamino)purin-9-yl]-N-ethyl-3,4-dihydroxy-oxolane-2-carboxamide is used as a pharmaceutical compound for its potential involvement in biological processes. The presence of a purine base and functional groups suggests that it may interact with other molecules and cellular processes, making it a candidate for drug development and therapeutic applications.
Used in Research Applications:
In the field of scientific research, (2S,3S,4R,5R)-5-[6-amino-2-(phenethylamino)purin-9-yl]-N-ethyl-3,4-dihydroxy-oxolane-2-carboxamide serves as a valuable compound for studying the interactions between nucleic acids and other biomolecules. Its unique structure and functional groups allow researchers to investigate its role in various biological processes and potentially discover new mechanisms of action.

InChI:InChI=1/C20H25N7O4/c1-2-22-18(30)15-13(28)14(29)19(31-15)27-10-24-12-16(21)25-20(26-17(12)27)23-9-8-11-6-4-3-5-7-11/h3-7,10,13-15,19,28-29H,2,8-9H2,1H3,(H,22,30)(H3,21,23,25,26)/t13-,14+,15-,19+/m0/s1

Upstream product

• 24639-06-3 ((3aR,4R,6R,6aR)-6-(6-amino-2-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol 
• 1195939-25-3 2-fluoro-2',3'-O-isopropylideneadenosine-5'-N-ethylcarboxamide 
• 64-04-0 phenethylamine 
• 146-77-0 2-Chloroadenosine 
• 120225-75-4 2-chloro-2',3'-O-isopropylideneadenosine-5'-N-ethylcarboxamide 
• 72209-19-9 2-chloro-2',3'-O-isopropylideneadenosine-5'-carboxylic acid 
• 120225-77-6 2-(2-phenyl)ethylamino-2',3'-O-isopropylideneadenosine-5'-N-ethylcarboxamide 

Relevant academic research and scientific papers

Synthesis and pharmacological evaluation of dual acting antioxidant a 2A adenosine receptor agonists

A series of adenosine-5′-N-alkylcarboxamides and N 6-(2,2-diphenylethyl)adenosine-5′-N-alkylcarboxamides bearing antioxidant moieties in the 2-position were synthesized from the versatile intermediate, O6-(benzotriazol-1-yl)-2-fluoro

Linear and convergent approaches to 2-substituted adenosine-5′-N-alkylcarboxamides

Herein we report both linear and convergent pathways for the preparation of 2-alkynyl substituted adenosine-5′-N-ethylcarboxamides via the versatile synthetic intermediate, 2-iodoadenosine-5′-N-ethylcarboxamide (13). The linear approach afforded 13 in an overall yield of 30% from guanosine over eight synthetic steps. The convergent approach was shorter, but proceeded in lower yield (five steps, 20% yield). Both approaches compare favourably with previously reported syntheses of 13, which has been prepared in 15% yield from guanosine over nine steps. 2-Iodoadenosine-5′-N-ethylcarboxamide (13) was subsequently converted to HENECA (2) and PHPNECA (3) to exemplify the utility of this approach for the preparation of?potent A2A adenosine receptor agonists. The linear approach was also amenable to the synthesis of 2-fluoropurine ribosides, which were subsequently elaborated into 2-alkylaminoadenosine-5′-N-ethylcarboxamides. Furthermore, both of these synthetic approaches are readily amenable to the synthesis of adenosine analogues with varied 2-, 6- and 5′-substitution patterns.

2-(Arylalkylamino)adenosin-5'-uronamides: A New Class of Highly Selective Adenosine A2 Receptor Ligands

The synthesis and receptor-binding profiles at adenosine receptor subtypes for a series of 2-(arylalkylamino)adenosin-5'-uronamides is described.Halogenated 2-phenethylamino analogues such as 3e show greater than 200-fold selectivity for the A2 receptor s