1202616-64-5Relevant articles and documents
2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors
Siu, Michael,Pastor, Richard,Liu, Wendy,Barrett, Kathy,Berry, Megan,Blair, Wade S.,Chang, Christine,Chen, Jacob Z.,Eigenbrot, Charles,Ghilardi, Nico,Gibbons, Paul,He, Haiying,Hurley, Christopher A.,Kenny, Jane R.,Cyrus Khojasteh,Le, Hoa,Lee, Leslie,Lyssikatos, Joseph P.,Magnuson, Steve,Pulk, Rebecca,Tsui, Vickie,Ultsch, Mark,Xiao, Yisong,Zhu, Bing-Yan,Sampath, Deepak
, p. 5014 - 5021 (2013)
The advancement of a series of ligand efficient 2-amino-[1,2,4]triazolo[1, 5-a]pyridines, initially identified from high-throughput screening, to a JAK2 inhibitor with pharmacodynamic activity in a mouse xenograft model is disclosed.
TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS
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Page/Page column 113, (2010/01/12)
A compound of Formula (I), enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A