1202764-93-9

Upstream product

• 100487-81-8 2-(4-bromo-2-nitro-phenyl)malonic acid dimethyl ester 
• 74-88-4 methyl iodide 
• 364-73-8 4-Bromo-1-fluoro-2-nitrobenzene 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 90725-50-1 (3-RS)-6-bromo-2,3-dihydro-3-methyl-1H-indole-2-one 

Relevant academic research and scientific papers

PYRIDINONE DERIVATIVES AND THEIR USE AS SELECTIVE ALK-2 INHIBITORS

The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

ALKYNYL ALCOHOLS AS KINASE INHIBITORS

Selected compounds are effective for prophylaxis and treatment of inflammation and inflammatory disorders, such as NIK-mediated disorders. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, inflammation and the like.