100487-81-8

Basic information

• Product Name: Propanedioic acid, (4-broMo-2-nitrophenyl)-, diMethyl ester
• Synonyms: Propanedioic acid, (4-broMo-2-nitrophenyl)-, diMethyl ester;Propanedioic acid, 2-(4-broMo-2-nitrophenyl)-, 1,3-diMethyl ester;dimethyl 2-(4-bromo-2-nitrophenyl)malonate;1,3-Dimethyl 2-(4-bromo-2-nitrophenyl)propanedioate
• CAS NO: 100487-81-8
• Molecular Formula: C₁₁H₁₀BrNO₆
• Molecular Weight: 332.1042
• Mol File: 100487-81-8.mol
• Article Data: 37

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Propanedioic acid, (4-broMo-2-nitrophenyl)-, diMethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, (4-broMo-2-nitrophenyl)-, diMethyl ester(100487-81-8)
• EPA Substance Registry System: Propanedioic acid, (4-broMo-2-nitrophenyl)-, diMethyl ester(100487-81-8)

Safety Data

• Hazardous Substances Data: 100487-81-8(Hazardous Substances Data)

Upstream product

• 3460-18-2 1,4-dibromo-2-nitrobenzene 
• 108-59-8 malonic acid dimethyl ester 
• 364-73-8 4-Bromo-1-fluoro-2-nitrobenzene 

Downstream Products

• 1202772-48-2 methyl 2-(4-bromo-2-nitrophenyl)-2-hydroxy-3-((2-hydroxyethyl)(methyl)amino)propanoate 
• 1202765-56-7 6-bromo-2',3',5',6'-tetrahydrospiro[dihydroindole-3,4'-pyran] 
• 1202765-72-7 methyl 2-(4-bromo-2-nitrophenyl)oxirane-2-carboxylate 
• 1190861-43-8 6-bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one 
• 90725-50-1 (3-RS)-6-bromo-2,3-dihydro-3-methyl-1H-indole-2-one 
• 893441-85-5 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline-2-one 
• 1098855-11-8 C₉H₆BrNO₆ 
• 1202765-70-5 methyl 2-(4-bromo-2-nitrophenyl)acrylate 
• 1291104-18-1 (4S,5R)-2,2-diethyl 4-methyl 4-(4-bromo-2-nitrophenyl)-5-phenylpyrrolidine-2,2,4-tricarboxylate 
• 1202764-93-9 dimethyl 2-(4-bromo-2-nitrophenyl)-2-methylmalonate 
• 6127-11-3 (4-bromo-2-nitrophenyl)acetic acid 
• 848649-94-5 6-bromoindoline-2-thione 
• 99365-40-9 6-bromo-2,3-dihydro-1H-indole-2-one 
• 100487-82-9 4-bromo-2-nitro-benzoic acid methyl ester 

Relevant articles and documents

PYRIDINONE DERIVATIVES AND THEIR USE AS SELECTIVE ALK-2 INHIBITORS

The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

8 - SUBSTITUTED 2 -AMINO - [1,2,4] TRIAZOLO [1, 5 -A] PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS

Compounds of the formula I in which R1, R2 and R4 have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of cancer, rheumatoid arthritis and / or systemic lupus

Iron(II) bromide-catalyzed intramolecular c-h bond amination [1,2]-shift tandem reactions of aryl azides

Iron(II) bromide catalyzes the transformation of ortho-substituted aryl azides into 2,3-disubstituted indoles through a tandem ethereal C-H bond amination [1,2]-shift reaction. The preference for the 1,2-shift component of the tandem reaction was established to be Me 1 2 Ph.