1202993-11-0

Basic information

• Product Name: 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic Acid
• Synonyms: 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic Acid;1H-Pyrazole-4-carboxylic acid, 5-chloro-3-(difluoroMethyl)-1-Methyl-;5-chloro-3-(difluoromethyl)-1-methylpyrazole-4-carboxylic acid
• CAS NO: 1202993-11-0
• Molecular Formula: C6H5ClF2N2O2
• Molecular Weight: 210.5659064
• Product Categories: Building Blocks;Pyrazole
• Mol File: 1202993-11-0.mol

Chemical Properties

• Boiling Point: 318.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.68±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.95±0.50(Predicted)
• CAS DataBase Reference: 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic Acid(1202993-11-0)
• EPA Substance Registry System: 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic Acid(1202993-11-0)

Safety Data

• Hazardous Substances Data: 1202993-11-0(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid is used as a building block or intermediate for the synthesis of pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs, particularly in the context of targeted research and development activities.
Used in Agrochemical Synthesis:
In the agrochemical industry, 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid is used as a precursor in the synthesis of agrochemical products. Its chemical reactivity and potential interactions with other compounds make it a valuable component in the creation of new pesticides or herbicides.
Used in Research and Development:
5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid is used as a research compound for exploring its chemical properties and potential applications in various fields. As a custom synthesized compound, it is often employed in specific targeted research projects to investigate its reactivity, stability, and possible uses in different chemical reactions or processes.

InChI:InChI=1S/C6H5ClF2N2O2/c1-11-4(7)2(6(12)13)3(10-11)5(8)9/h5H,1H3,(H,12,13)

Upstream product

• 660845-30-7 5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde 

Downstream Products

• 1373517-28-2 C₁₄H₁₄ClF₂N₃O 
• 1373536-42-5 [3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl][2-(3-methyl-benzyl)pyrrolidin-1-yl]methanone 
• 1352027-33-8 N-cyclopropyl-N-[2-(2,6-dichlorophenoxy)ethyl]-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide 
• 1351783-77-1 N-[1-(2,4-dichlorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide 
• 1255735-09-1 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxylic acid 

Relevant articles and documents

Synthesis of pyrazole-4-carboxamides as potential fungicide candidates

Abstract: A series of novel pyrazole-4-carboxamides were rationally designed, synthesized, and their structures were characterized by 1H NMR, 13C NMR and HRMS. Preliminary bioassay showed that four compounds 8g, 8j, 8o and 8s exhibited more than 90% and even completed inhibition against Alternaria solani at 100?μg/mL; and 8d displayed 100% inhibition against Fusarium oxysporum at the same concentration. Moreover, 8j exhibited good in vitro fungicidal activity against A. solani with EC50 value of 3.06?μg/mL, and it also displayed completed in vivo protective antifungal activity against A. solani on tomato at 10?mg/L, as boscalid did. The molecular docking results indicated that 8j exhibited the high affinity with SDH protein by H-bond and π–π stacking interactions, which may explain the reasons for its good activities. These data support that compound 8j could be used as a fungicide candidate for further study. Graphic abstract: A practical method for the synthesis of pyrazole-4-carboxamides were provided and evaluation of their antifungal activities.[Figure not available: see fulltext.].

A kind of air oxidation preparation 3-fluoroalkyl-1-substituted pyrazole-4-carboxylic acid

Provided is a method of preparing 3-fluoroalkyl-1-substituted pyrazol-4-carboxylic acid by air oxidation. The methoduses 3-fluoroalkyl-1-substituted pyrazol-4-formaldehyde as raw material for reaction in a neutral or alkaline condition under the action of a catalyst and with air as an oxidizing agent, to obtain 3-fluoroalkyl-1-substituted pyrazol-4-carboxylic acid. The method employs a mild, safe and clean reaction, and is suitable for industrial mass production.

N-BENZYL HETEROCYCLIC CARBOXAMIDES

The present invention relates to N-benzyl heterocyclic carboxamides derivatives or their thiocarboxamides derivatives, their process of preparation, their use as fungicide, particularly in the form of compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.

1-(HETEROCYCLIC CARBONYL)-2-SUBSTITUTED PYRROLIDINES

The present invention relates to fungicidal 1-(heterocyclic carbonyl)-2-substituted pyrrolidines and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in th

N-BENZYL HETEROCYCLIC CARBOXAMIDES

The present invention relates to N-benzyl heterocyclic carboxamidesderivatives or their thiocarboxamides derivatives, their process of preparation, their use as fungicide, particularly in the form of compositions, and methods for the control of phytopatho

N-HETARYLMETHYL PYRAZOLYLCARBOXAMIDES

The present invention relates to N-Hetarylmethyl pyrazolylcarboxamides derivatives or their thiocarboxamides derivatives, their process of preparation, their use as fungicide, particularly in the form of compositions.Formula (I), and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.

5-HALOGENOPYRAZOLE(THIO)CARBOXAMIDES

The present invention relates to novel 5-halogenopyrazole (thio) carboxamides of formula (I), their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions wherein Hal1, Hal2, T, R, L and Q are as defined in the claims.

DECAHYDRO-1,4-METHANONAPHTHALEN CARBOXAMIDES

The present invention relates to decahydro-1,4-methanonaphthalen carboxamide derivatives of formula (Ia) or (Ib); their process of preparation, their use as fungicide, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.

N-ARYL PYRAZOLE(THIO)CARBOXAMIDES

The present invention relates to novel (thio)carboxamides, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.

5-HALOGENOPYRAZOLECARBOXAMIDES

The present invention relates to novel 5-halogenopyrazole(thio)carboxamides, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, nota