660845-30-7

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde is used as a reactant in the preparation of pyrazole amide compounds for its antifungal properties. 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde plays a crucial role in the synthesis of these amide compounds, which are designed to target and inhibit the growth of fungi, offering potential therapeutic benefits in treating fungal infections.

Upstream product

• 74-88-4 methyl iodide 
• 68-12-2 N,N-dimethyl-formamide 
• 129922-58-3 1-methyl-3-difluoromethyl-5-hydroxy-1H-pyrazole 
• 352-24-9 ethyl 4,4-difluoro-3-oxobutyrate 

Downstream Products

• 1255735-09-1 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxylic acid 
• 1351783-77-1 N-[1-(2,4-dichlorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide 
• 1352027-33-8 N-cyclopropyl-N-[2-(2,6-dichlorophenoxy)ethyl]-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide 
• 1094484-55-5 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde 
• 1373517-28-2 C₁₄H₁₄ClF₂N₃O 
• 1373536-42-5 [3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl][2-(3-methyl-benzyl)pyrrolidin-1-yl]methanone 
• 1202993-11-0 5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of pyrazole-4-carboxamides as potential fungicide candidates

Abstract: A series of novel pyrazole-4-carboxamides were rationally designed, synthesized, and their structures were characterized by 1H NMR, 13C NMR and HRMS. Preliminary bioassay showed that four compounds 8g, 8j, 8o and 8s exhibited more than 90% and even completed inhibition against Alternaria solani at 100?μg/mL; and 8d displayed 100% inhibition against Fusarium oxysporum at the same concentration. Moreover, 8j exhibited good in vitro fungicidal activity against A. solani with EC50 value of 3.06?μg/mL, and it also displayed completed in vivo protective antifungal activity against A. solani on tomato at 10?mg/L, as boscalid did. The molecular docking results indicated that 8j exhibited the high affinity with SDH protein by H-bond and π–π stacking interactions, which may explain the reasons for its good activities. These data support that compound 8j could be used as a fungicide candidate for further study. Graphic abstract: A practical method for the synthesis of pyrazole-4-carboxamides were provided and evaluation of their antifungal activities.[Figure not available: see fulltext.].

Ethyl isoxazoline derivative and application thereof

The invention provides an ethyl isoxazoline derivative and application thereof. Specifically, the invention provides a compound as shown in a formula (Ia) or a stereoisomer, nitrogen oxide or salt of the compound as shown in the formula (Ia), and a preparation method thereof. N is 0, 1 or 2; R is C1-6 alkyl or phenyl optionally substituted by 1 to 5 halogen atoms; and X is chlorine, a C1-6 alkoxy group or a halogenated C1-6 alkoxy group. Furthermore, the invention provides a composition containing the compounds and application of the composition in agriculture, especially application of the composition as a herbicide active ingredient for controlling unwanted plants.

ISOXAZOLINE DERIVATIVES AND THEIR USES IN AGRICULTURE

A compound of formula (I) is provided, it can be used in agriculture, particularly used as herbicide for controlling unwanted plants.

OXAZOLINE DERIVATIVES AND USES IN AGRICULTURE THEREOF

Provided are isoxazoline derivatives having formula (Ia), or a stereoisomer, an N-oxide or a salt thereof, preparation methods thereof, compositions containing these compounds and uses in agriculture thereof, particularly uses as active ingredients of herbicide for controlling unwanted plants.

Diphenyl ether structure-containing pyrazolecarboxamide compound and its preparation method and use

The invention discloses a diphenyl ether structure-containing pyrazolecarboxamide compound. A general structural formula and substituent groups are defined in the specification. The diphenyl ether structure-containing pyrazolecarboxamide compound is suita

PROCESS FOR PREPARING 1-ALKYL-3-FLUOROALKYL-1H-PYRAZOLE-4-CARBOXYLIC ACID CHLORIDES

The present invention relates to a novel method for preparing 1-alkyl-3-fluoroalkyl-1H-pyrazole-4-carbonyl chlorides, a useful precursor for the preparation of fungicides, by means of reductive dehalogenation, starting from N-alkyl-3-haloalkyl-5-halopyrazolecarbaldehyde.

PHARMACEUTICAL COMPOSITION

The present invention provides compounds of Formula (I): along with pharmaceutical compositions containing the same, and methods of use thereof in subjects in need of treatment.

Preparing 5-fluoro-1-alkyl-3-fluoroalkyl-1H-pyrazole-4-carbonyl chlorides

The present invention relates to a novel process for preparing 5-fluoro-1-alkyl-3-fluoroalkyl-1H-pyrazole-4-carbonyl chlorides, a useful intermediate in the manufacture of fungicides.

Herbicide compositions

A herbicidal composition which comprises i) an isoxazoline derivative represented by the following general formula (I) or its salt and ii) at least one compound selected from the Group A: Formula (I) wherein R1, R2, R3, R4, R5 and R6 are defined in the specification.