1255735-09-1

Basic information

• Product Name: 3-(DifluoroMethyl)-5-fluoro-1-Methyl-1H-Pyrazole-4-carboxylic acid
• Synonyms: 3-(DifluoroMethyl)-5-fluoro-1-Methyl-1H-Pyrazole-4-carboxylic acid
• CAS NO: 1255735-09-1
• Molecular Formula: C₆H₅F₃N₂O₂
• Molecular Weight: 194.1113096
• Mol File: 1255735-09-1.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 302.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.63±0.1 g/cm3(Predicted)
• PKA: 2.19±0.36(Predicted)
• CAS DataBase Reference: 3-(DifluoroMethyl)-5-fluoro-1-Methyl-1H-Pyrazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(DifluoroMethyl)-5-fluoro-1-Methyl-1H-Pyrazole-4-carboxylic acid(1255735-09-1)
• EPA Substance Registry System: 3-(DifluoroMethyl)-5-fluoro-1-Methyl-1H-Pyrazole-4-carboxylic acid(1255735-09-1)

Safety Data

• Hazardous Substances Data: 1255735-09-1(Hazardous Substances Data)

Upstream product

• 1255735-07-9 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carbonyl fluoride 
• 129922-58-3 1-methyl-3-difluoromethyl-5-hydroxy-1H-pyrazole 
• 660845-30-7 5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde 
• 1255947-44-4 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carbaldehyde 
• 1202993-11-0 5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid 
• 1255735-05-7 1?methyl?3?difluoromethyl?5?chloropyrazole?4?carbonyl chloride 

Downstream Products

• 1352027-33-8 N-cyclopropyl-N-[2-(2,6-dichlorophenoxy)ethyl]-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide 

Relevant articles and documents

Expanding the Chemical Space of Succinate Dehydrogenase Inhibitors via the Carbon-Silicon Switch Strategy

The carbon-silicon switch strategy has become a key technique for structural optimization of drugs to widen the chemical space, increase drug activity against targeted proteins, and generate novel and patentable lead compounds. Flubeneteram, targeting succinate dehydrogenase (SDH), is a promising fungicide candidate recently developed in China. We describe the synthesis of novel SDH inhibitors with enhanced fungicidal activity to enlarge the chemical space of flubeneteram by employing the C-Si switch strategy. Several of the thus formed flubeneteram-silyl derivatives exhibited improved fungicidal activity against porcine SDH compared with the lead compound flubeneteram and the positive controls. Disease control experiments conducted in a greenhouse showed that trimethyl-silyl-substituted compound W2 showed comparable and even higher fungicidal activities compared to benzovindiflupyr and flubeneteram, respectively, even with a low concentration of 0.19 mg/L for soybean rust control. Furthermore, compound W2 encouragingly performed slightly better control than azoxystrobin and was less active than benzovindiflupyr at the concentration of 100 mg/L against soybean rust in field trials. The computational results showed that the silyl-substituted phenyl moiety in W2 could form strong van der Waals (VDW) interactions with SDH. Our results indicate that the C-Si switch strategy is an effective method for the development of novel SDH inhibitors.

N-BENZYL HETEROCYCLIC CARBOXAMIDES

The present invention relates to N-benzyl heterocyclic carboxamides derivatives or their thiocarboxamides derivatives, their process of preparation, their use as fungicide, particularly in the form of compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.

N-BENZYL HETEROCYCLIC CARBOXAMIDES

The present invention relates to N-benzyl heterocyclic carboxamidesderivatives or their thiocarboxamides derivatives, their process of preparation, their use as fungicide, particularly in the form of compositions, and methods for the control of phytopatho