120309-35-5

Upstream product

• 123-62-6 propionic acid anhydride 
• 99-59-2 3-amino-4-methoxynitrobenzene 
• 79-03-8 propionyl chloride 

Downstream Products

• 959687-60-6 C₃₅H₄₂N₄O₃ 
• 959687-58-2 C₃₅H₄₀N₂O₃S 
• 943519-86-6 C₂₂H₃₀N₄O₄S 
• 943519-41-3 5-(2,4-bisbenzyloxy-5-isopropylphenyl)-4-[4-methoxy-3-(methyl(propyl)amino)phenyl]-4H-[1,2,4]triazol-3-ol 
• 943519-45-7 N-(5-isothiocyanato-2-methoxyphenyl)-N-methylpropylamine 
• 943519-39-9 4-methoxy-N³-methyl-N³-propylbenzene-1,3-diamine 
• 943519-44-6 N-(2-methoxy-5-nitrophenyl)-N-methylpropylamine 
• 943519-40-2 2,4-bisbenzyloxy-5-isopropyl-N-[4-methoxy-3-(methyl(propyl)amino)phenyl]benzamide 
• 1400659-71-3 C₁₇H₁₈N₂O₃ 
• 169321-23-7 N-(5-amino-2-methoxyphenyl)propionamide 
• 943519-43-5 N-(2-methoxy-5-nitrophenyl)-N-methylpropionamide 

Relevant academic research and scientific papers

Method for treating proliferative disorders associated with mutations in c-Met

The present invention relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating c-Met associated cancers, in a subject in need thereof.

Synthesis and antiviral activity of substituted bisaryl amide compounds as novel influenza virus inhibitors

The influenza virus is a persistent cause of mortality and morbidity on an annual basis and thus presents itself as an important target for pharmaceutical investigation. In this work, substituted bisaryl amide compounds were found to be a new class of potential anti-influenza agents, and a series of substituted bisaryl amide compounds were synthesised and evaluated for their anti-influenza virus activities. The analysis of the results produced a preliminary structure-activity relationship study (SAR). Compounds 1a, 1g, 1h, 1j, 1l and 1n exhibited clear antiviral activities against the influenza A (A/Guangdong Luohu/219/2006, H1N1) virus with 50% inhibitory concentrations (IC50) for virus growth ranging from 12.5 to 59.0 μM. Specifically, compound 1j also possessed antiviral activity against both oseltamivir-resistant influenza (A/Jinnan/15/2009) virus and influenza B (B/Jifang/13/97) virus with IC 50 values of 9.2 μM and 21.4 μM, respectively. Compound 1j is thus worth further investigation as an anti-influenza virus candidate.

Method for treating proliferative disorders associated with protooncogene products

The present invention relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating Bcr-Abl, FLT-3, EGFR, c-Kit, B-raf, and NPM-ALK associated cancers, in a subject in need thereof.

METHOD FOR TREATING INFLAMMATORY DISORDERS

The present invention relates to a method for suppressing the immune system in a subject in need thereof, and a method for treating an inflammatory or immune disorder in a subject in need thereof.

METHOD FOR TREATING INFECTIONS

The present invention relates to compounds that inhibit the activity of Hsp90 and methods of using these compounds for treating or preventing infection.

METHOD FOR INHIBITING TOPOISOMERASE II

The present invention relates to compounds that inhibit the activity of Hsp90 and inhibit topoisomerase II.

TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

Triazole compounds that modulate HSP90 activity

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

METHOD FOR TREATING NON-HODGKIN'S LYMPHOMA

The present invention relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating non-Hodgkin's lymphoma, in a subject in need thereof.

QUADRATIC NONLINEAR OPTICAL ELEMENT

A high-performance quadratic nonlinear optical element which can exhibit a large nonlinear optical effect. The element contains a part which comprises a non-centrosymmetric monoclinic crystal, belonging to the space group Cc and the point group #9, of 4'-nitrobenzylidene-3-alkanoylamino-4-methoxyaniline of formula (I) or derivatives thereof wherein at least part of the hydrogen atoms are deuterated, and which is provided with at least one substantially optically flat surface which admits or transmits rays of light having a large electric oscillation vector component in the direction of the axis of maximum absorption present in the ac face of a nuclear crystal. In formula (I) R represents a C1 or C2 alkyl or haloalkyl.