120362-30-3 Usage
Uses
Used in Pharmaceutical Development:
Phosphonic acid, [[1-[[(methylsulfonyl)oxy]methyl]-2-(phenylmethoxy)ethoxy]methyl]-, diethyl ester-R is used as a key intermediate in the synthesis of novel pharmaceuticals for various therapeutic applications. Its unique structure allows for the creation of new drug candidates with potential benefits in treating diseases and medical conditions.
Used in Industrial Chemical Synthesis:
In the chemical industry, Phosphonic acid, [[1-[[(methylsulfonyl)oxy]methyl]-2-(phenylmethoxy)ethoxy]methyl]-, diethyl ester-R is employed as a building block for the development of new industrial chemicals. Its functional groups facilitate its incorporation into larger molecules, leading to the creation of innovative products with improved properties and performance.
Used in Scientific Research:
Phosphonic acid, [[1-[[(methylsulfonyl)oxy]methyl]-2-(phenylmethoxy)ethoxy]methyl]-, diethyl ester-R is utilized as a research tool in various scientific studies. Its complex structure and reactivity make it an interesting subject for investigations into chemical reactions, mechanisms, and the development of new synthetic methodologies.
Check Digit Verification of cas no
The CAS Registry Mumber 120362-30-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,3,6 and 2 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 120362-30:
(8*1)+(7*2)+(6*0)+(5*3)+(4*6)+(3*2)+(2*3)+(1*0)=73
73 % 10 = 3
So 120362-30-3 is a valid CAS Registry Number.
InChI:InChI=1/C16H27O8PS/c1-4-22-25(17,23-5-2)14-21-16(13-24-26(3,18)19)12-20-11-15-9-7-6-8-10-15/h6-10,16H,4-5,11-14H2,1-3H3/t16-/m1/s1
120362-30-3Relevant academic research and scientific papers
Synthesis and antiviral activity of the nucleotide analogue (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cystosine
Bronson,Ghazzouli,Hitchcock,Webb II,Martin
, p. 1457 - 1463 (2007/10/02)
The acyclic nucleotide analogue (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine (2, HPMPC) was prepared on a multigram scale in 18% overall yield starting from (R)-2,3-O-isopropylideneglycerol. The key step in the nine-step synthetic route is coupling of cytosine with the side-chain derivative 8 which bears a protected phosphonylmethyl ether group. In vitro data showed that HPMPC has good activity against herpes simplex virus types 1 and 2, although it was 10-fold less potent that acyclovir [ACV, 9-[(2-hydroxyethoxy)methyl]guanine]. By comparison, HPMPC exhibited greater activity than ACV against a thymidine kinase deficient strain of HSV 1 and was more potent than ganciclovir [DHPG, 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine] against human cytomegalovirus. In vivo, HPMPC showed exceptional potency against HSV 1 systemic infection in mice, having an ED50 of 0.1 mg/kg per day (ip) compared with 50 mg/kg per day for ACV. HPMPc was also more efficacious than ACV in the topical treatment of HSV 1 induced cutaneous lesions in guinea pigs.
