120371-27-9

Basic information

• Product Name: N-(2-fluorophenyl)-N-methylacetamide
• Synonyms: N-(2-fluorophenyl)-N-methylacetamide
• CAS NO: 120371-27-9
• Molecular Weight: 167.183
• Mol File: 120371-27-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(2-fluorophenyl)-N-methylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-fluorophenyl)-N-methylacetamide(120371-27-9)
• EPA Substance Registry System: N-(2-fluorophenyl)-N-methylacetamide(120371-27-9)

Safety Data

• Hazardous Substances Data: 120371-27-9(Hazardous Substances Data)

Upstream product

• 1978-38-7 2-fluoro-N-methylaniline 
• 75-36-5 acetyl chloride 

Downstream Products

• 1386996-15-1 N-(2-fluorophenyl)-N-methyl-2-(triphenylsilyl)acetamide 

Relevant articles and documents

Method for preparing aryl amide compound by catalyzing carbonylation of aryl tertiary amine through metal-free catalytic system

The invention discloses a method for preparing aryl amide compounds by catalyzing aryl tertiary amine carbonylation through a metal-free catalytic system. The method is characterized in that in a reaction solvent, carbonyl molybdenum is used as a substitute carbonyl source, an organic base is used as a main catalyst, and methyl iodide is used as a catalyst promoter; and carbonylation of aryl tertiary amine is catalyzed under normal pressure to prepare the aryl amide compound. The reaction formula of synthesis is shown in the specification, wherein R is one of CH3, C2H5, pheyl, F, CL, Br or CN. According to the present invention, the organic base is adopted as the main catalyst, the iodomethane is adopted as the catalyst promoter, the carbonyl molybdenum is adopted as the substitute carbonyl source, and the aryl tertiary amine carbonylation can be efficiently catalyzed at the reaction temperature of 140 DEG C to prepare the aryl amide compound, so that the atom economy of the reaction is effectively improved, and a wide application prospect is provided; the molybdenum carbonyl is used as the substitute carbonyl source, so that the potential safety hazard of carbon monoxide is avoided; and the reaction can be carried out under normal pressure in the reaction process, and high-pressure reaction equipment is not needed.