120375-16-8

Upstream product

• 631-61-8 ammonium acetate 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 86212-34-2 (1R,2S)-1,2-bis(4-chlorophenyl)ethane-1,2-diamine 
• 1360627-29-7 4,5-bis(4-chlorophenyl)-N-((S)-1-(diethylamino)-1-oxopropan-2-yl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carboxamide 
• 1360627-30-0 C₃₄H₃₉Cl₂N₅O₄ 
• 1360627-31-1 4,5-bis(4-chlorophenyl)-N-((R)-1-(diethylamino)-1-oxopropan-2-yl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carboxamide 
• 1360627-32-2 4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-N-((R)-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl)-4,5-dihydroimidazole-1-carboxamide 
• 1360627-13-9 (2R)-ethyl 2-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carboxamido)propanoate 
• 1360627-14-0 (2S)-ethyl 2-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carboxamido)propanoate 
• 1360627-18-4 (2R)-2-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carboxamido)propanoic acid 

Relevant academic research and scientific papers

Design, synthesis and CoMFA studies of N1-amino acid substituted 2,4,5-triphenyl imidazoline derivatives as p53-MDM2 binding inhibitors

A series of novel N1-amino-acid substituted 2,4,5-triphenyl imidazoline derivatives was designed and synthesized based on our previous studies. All synthesized target compounds were screened for their p53-MDM2 binding inhibitory activities and anti-proliferative activities against five cancer cell lines. Among them, twelve compounds displayed improved binding inhibitory activities and most compounds showed higher cell growth inhibition activities with IC 50 values in the low micromolar range. Compound 6c exhibited marked p53-MDM2 binding inhibitory activity (IC50 = 0.59 μM) which was eightfold more potent than that of Nutlin-1 (IC50 = 4.78 μM). CoMFA analysis was performed based on obtained biological data and resulted in a statistically significant CoMFA model with high predict abilities (q 2 = 0.645, r2 = 0.979).