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2-Chloro-1-(2,5-dimethoxyphenyl)ethanone, with the CAS number 1204-22-4, is a light-yellow crystalline compound that is primarily utilized in the field of organic synthesis. It is known for its unique chemical properties that make it a valuable component in the creation of various organic compounds.

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  • 1204-22-4 Structure
  • Basic information

    1. Product Name: 2-CHLORO-1-(2,5-DIMETHOXYPHENYL)ETHANONE
    2. Synonyms: 2-Chloro-1-(2,5-dimethoxyphenyl)ethanol;2-chloro-1-(2,5-diMethoxyphenyl)ethan-1-ol;2-Chloro-2',5'-diMethoxyacetophenone;NSC 118988;2‐(Chloroacetyl)‐catechol dimethyl ether
    3. CAS NO:1204-22-4
    4. Molecular Formula: C10H11ClO3
    5. Molecular Weight: 214.65
    6. EINECS: N/A
    7. Product Categories: Aromatics
    8. Mol File: 1204-22-4.mol
  • Chemical Properties

    1. Melting Point: 88-90°C
    2. Boiling Point: 318.7 °C at 760 mmHg
    3. Flash Point: 134.9 °C
    4. Appearance: /
    5. Density: 1.19g/cm3
    6. Vapor Pressure: 0.000355mmHg at 25°C
    7. Refractive Index: 1.516
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-CHLORO-1-(2,5-DIMETHOXYPHENYL)ETHANONE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-CHLORO-1-(2,5-DIMETHOXYPHENYL)ETHANONE(1204-22-4)
    12. EPA Substance Registry System: 2-CHLORO-1-(2,5-DIMETHOXYPHENYL)ETHANONE(1204-22-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1204-22-4(Hazardous Substances Data)

1204-22-4 Usage

Uses

Used in Organic Synthesis:
2-Chloro-1-(2,5-dimethoxyphenyl)ethanone is used as a key intermediate in the synthesis of various organic compounds. Its unique structure and reactivity allow it to be a versatile building block for the development of new molecules with potential applications in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Chloro-1-(2,5-dimethoxyphenyl)ethanone is used as a starting material for the synthesis of various pharmaceutical compounds. Its ability to react with other molecules and form new chemical entities makes it a valuable asset in the development of new drugs and therapeutic agents.
Used in Chemical Research:
2-Chloro-1-(2,5-dimethoxyphenyl)ethanone is also used in chemical research as a model compound to study various reaction mechanisms and to understand the behavior of similar molecules. This helps researchers to develop new synthetic strategies and improve existing ones, ultimately contributing to the advancement of chemical science.
Used in Material Science:
In the field of material science, 2-Chloro-1-(2,5-dimethoxyphenyl)ethanone can be used as a component in the development of new materials with specific properties. Its unique chemical structure can be exploited to create materials with tailored characteristics, such as improved stability, reactivity, or selectivity, which can be applied in various industrial applications.

Check Digit Verification of cas no

The CAS Registry Mumber 1204-22-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,0 and 4 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1204-22:
(6*1)+(5*2)+(4*0)+(3*4)+(2*2)+(1*2)=34
34 % 10 = 4
So 1204-22-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H11ClO3/c1-13-7-3-4-10(14-2)8(5-7)9(12)6-11/h3-5H,6H2,1-2H3

1204-22-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-chloro-1-(2,5-dimethoxyphenyl)ethanone

1.2 Other means of identification

Product number -
Other names 2-Chlor-1-(2,5-dimethoxy-phenyl)-aethanon

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1204-22-4 SDS

1204-22-4Relevant articles and documents

Collective enantioselective total synthesis of (+)-sinensilactam A, (+)-lingzhilactone B and (-)-lingzhiol: Divergent reactivity of styrene

Fan, Hui-Lan,Li, Cheng-Ji,Luo, Sanzhong,Qin, Hong-Bo,Zhang, Da-Wei,Zhang, Wenzhao

, p. 10066 - 10069 (2020)

The collective total synthesis of (+)-sinensilactam A, (+)-lingzhilactone B, (+)-lingzhilactone C and (-)-lingzhiol has been accomplished from a common epoxide intermediate 9. Chemoselective epoxy opening with either an aryl or alkene moiety of styrene le

Discovery of Novel Polycyclic Heterocyclic Derivatives from Evodiamine for the Potential Treatment of Triple-Negative Breast Cancer

Chen, Zhe-Sheng,Li, Dahong,Qiu, Yangyi,Wu, Liang,Xu, Jinyi,Xu, Shengtao,Yang, Dong-Hua,Yao, Hong,Zhou, Manzhen

supporting information, p. 17346 - 17365 (2021/12/09)

Evodiamine (Evo) is a quinazolinocarboline alkaloid found in Evodia rutaecarpa and exhibits moderate antiproliferative activity. Herein, we report using a scaffold-hopping approach to identify a series of novel polycyclic heterocyclic derivatives based on Evo as the topoisomerase I (Top1) inhibitor for the treatment of triple-negative breast cancer (TNBC), which is an aggressive subtype of breast cancer with limited treatment options. The most potent compound 7f inhibited cell growth in a human breast carcinoma cell line (MDA-MB-231) with an IC50 value of 0.36 μM. Further studies revealed that Top1 was the target of 7f, which directly induced irreversible Top1-DNA covalent complex formation or induced an oxidative DNA lesion through an indirect mechanism mediated by reactive oxygen species. More importantly, in vivo studies showed that 7f exhibited potent antitumor activity in a TNBC-patient-derived tumor xenograft model. These results suggest that compound 7f deserves further investigation as a promising candidate for the treatment of TNBC.

Novel evodiamine derivatives as well as preparation method and application of novel evodiamine derivatives

-

Paragraph 0098; 0100, (2018/03/13)

The invention relates to the field of medicinal chemistry and particularly relates to novel evodiamine derivatives and also discloses a preparation method of the novel evodiamine derivatives and an application of the novel evodiamine derivatives to treatm

Synthesis of midodrine HCI from a novel intermediate 1-(2′,5′-dimethoxyphenyl)-2-azidoethanone

-

, (2008/06/13)

Midodrine hydrochloride, ±1-(2′,5′-dimethoxyphenyl)-2-glycineamido-ethanol-(1)-HCl, is prepared from a novel intermediate, 1-(2′,5′-dimethoxyphenyl)-2-azidoethanone.

α-Chlorination of Aromatic Acetyl Derivatives with Benzyltrimethylammonium Dichloroiodate

Kajigaeshi, Shoji,Kakinami, Takaaki,Moriwaki, Masayuki,Fujisaki, Shizuo,Maeno, Kimihiro,Okamoto, Tsuyoshi

, p. 545 - 546 (2007/10/02)

Reaction of aromatic acetyl derivatives with benzyltrimethylammonium dichloroiodate in refluxing dichloroethane/methanol for several hours gave α-chloroacetyl derivatives in good yields.

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