490-59-5Relevant articles and documents
Insights into the hydronium-ion storage of alloxazine in mild electrolyte
Hou, Xuesen,Liang, Jing,Liu, Chang,Nian, Qingshun,Sun, Tianjiang,Tao, Zhanliang,Xu, XiuFang,Zheng, Shibing
, p. 21983 - 21987 (2020)
Here, it is shown for the first time that alloxazine (ALO) can reversibly store hydronium ions in 1 M Mg(NO3)2 electrolyte. Comprehensive analyses confirm that Mg2+ ions, which possess catalytic properties, can promote hydronium-ion transfer by forming a
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Karrer et al.
, p. 1165,1167, 1168 (1934)
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Discovery of isoalloxazine derivatives as a new class of potential anti-Alzheimer agents and their synthesis
Kanhed, Ashish M.,Sinha, Anshuman,Machhi, Jatin,Tripathi, Ashutosh,Parikh, Zalak S.,Pillai, Prakash P.,Giridhar, Rajani,Yadav, Mange Ram
, p. 7 - 12 (2015/06/08)
This article describes discovery of a novel and new class of cholinesterase inhibitors as potential therapeutics for Alzheimer's disease. A series of novel isoalloxazine derivatives were synthesized and biologically evaluated for their potential inhibitory outcome for both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). These compounds exhibited high activity against both the enzymes AChE as well as BuChE. Of the synthesized compounds, the most potent isoalloxazine derivatives (7m and 7q) showed IC50 values of 4.72 μM and 5.22 μM respectively against AChE; and, 6.98 μM and 5.29 μM respectively against BuChE. These two compounds were further evaluated for their anti-aggregatory activity for β-amyloid (Aβ) in presence and absence of AChE by performing Thioflavin-T (ThT) assay and Congo red (CR) binding assay. In order to evaluate cytotoxic profile of these two potential compounds, cell viability assay of SH-SY5Y human neuroblastoma cells was performed. Further, to understand the binding behavior of these two compounds with AChE and BuChE enzymes, docking studies have been reported.
Electron-deficient alloxazinium salts: Efficient organocatalysts of mild and chemoselective sulfoxidations with hydrogen peroxide
Menova, Petra,Dvorakova, Hana,Eigner, Vaclav,Ludvik, Jiri,Cibulka, Radek
, p. 3451 - 3462 (2013/12/04)
A series of substituted alloxazinium perchlorates has been prepared and tested as catalysts for the oxidation of sulfides to sulfoxides with hydrogen peroxide. The logarithms of the observed rate constants of thioanisole oxidation correlate with the Hammett σ constants of the substituents on the alloxazinium catalysts, as well as with their reduction potentials E 0′ and their pKR+ values, representing the alloxazinium salt/pseudobase equilibrium. The stronger the electron-withdrawing substituent, the more efficient is the alloxazinium catalyst. The alloxazinium salts with a cyano or trifluoromethyl group in position 8 proved to be the most efficient, operating at room temperature at small loadings, down to 0.1 mol%, achieving turnover number values of up to 640 and acceleration by a factor of 350 relative to the non-catalyzed oxidation. The 8-cyanoalloxazinium perchlorate was evaluated as the best catalyst; however, due to its relatively good accessibility, the 8-(trifluoromethyl)alloxazinium perchlorate seems to be the catalyst of choice for sulfoxidations with hydrogen peroxide. It was successfully tested for the sulfoxidation of a series of aliphatic and aromatic sulfides on a preparative scale. It produced the corresponding sulfoxides in quantitative conversions and with high isolated yields (87-98%). No over-oxidation to sulfone was ever observed. Copyright
