36818-07-2

Basic information

• Product Name: 3-OXO-3,4-DIHYDRO-QUINOXALINE-2-CARBOXYLIC ACID
• Synonyms: 3-OXO-3,4-DIHYDRO-QUINOXALINE-2-CARBOXYLIC ACID;TIMTEC-BB SBB000282;3,4-DIHYDRO-3-OXO-2-QUINOXALINECARBOXYLIC ACID;Nsc65995;Ethyl 3-Oxo-3,4-dihydro-2-quinoxalinecarboxylate;Ethyl 3-oxo-3,4-dihydroquinoxaline-2-carboxylate;3-keto-4H-quinoxaline-2-carboxylic acid ethyl ester;3-oxo-4H-quinoxaline-2-carboxylic acid ethyl ester
• CAS NO: 36818-07-2
• Molecular Formula: C₁₁H₁₀N₂O₃
• Molecular Weight: 190.16
• Mol File: 36818-07-2.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 371.9°Cat760mmHg
• Flash Point: 178.7°C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 4.66E-06mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: 3-OXO-3,4-DIHYDRO-QUINOXALINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-OXO-3,4-DIHYDRO-QUINOXALINE-2-CARBOXYLIC ACID(36818-07-2)
• EPA Substance Registry System: 3-OXO-3,4-DIHYDRO-QUINOXALINE-2-CARBOXYLIC ACID(36818-07-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 36818-07-2(Hazardous Substances Data)

Usage

General Description

3-OXO-3,4-DIHYDRO-QUINOXALINE-2-CARBOXYLIC ACID is a chemical compound with the molecular formula C9H7NO3. It is a quinoxaline derivative that contains a carboxylic acid group and a ketone group. 3-OXO-3,4-DIHYDRO-QUINOXALINE-2-CARBOXYLIC ACID is used in the pharmaceutical industry as a starting material for the synthesis of various drugs and bioactive molecules. It exhibits potential antimicrobial, antiviral, and anti-inflammatory properties, making it a valuable building block for the development of new therapeutic agents. Additionally, its unique chemical structure and reactivity make it a valuable tool for chemical research and development.

InChI:InChI=1/C11H10N2O3/c1-2-16-11(15)9-10(14)13-8-6-4-3-5-7(8)12-9/h3-6H,2H2,1H3,(H,13,14)

Upstream product

• 64-17-5 ethanol 
• 1204-75-7 3-hydroxyquinoxaline-2-carboxylic acid 
• 105-53-3 diethyl malonate 
• 95-54-5 1,2-diamino-benzene 
• 609-09-6 Diethyl ketomalonate 
• 685-87-0 Diethyl 2-bromomalonate 
• 49679-45-0 ethyl 3-chloroquinoxaline-2-carboxylate 
• 59743-08-7 diethyl 2,3-dioxosuccinate 
• 36818-08-3 ethyl 1,2,3,4-tetrahydro-3-oxoquinoxaline-2-carboxylate 
• 1436-59-5 cis-cyclohexane-1,2-diamine 
• 631-22-1 diethyl dibromomalonate 

Downstream Products

• 49679-45-0 ethyl 3-chloroquinoxaline-2-carboxylate 

Relevant articles and documents

Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors

We identified a new series of quinoxaline-2-carboxylic acid derivatives, targeting the human proviral integration site for Moloney murine leukemia virus-1 (HsPim-1) kinase. Seventeen analogues were synthesized providing useful insight into structure-activity relationships studied. Docking studies realized in the ATP pocket of HsPim-1 are consistent with an unclassical binding mode of these inhibitors. The lead compound 1 was able to block HsPim-1 enzymatic activity at nanomolar concentrations (IC50 of 74 nM), with a good selectivity profile against a panel of mammalian protein kinases. In vitro studies on the human chronic myeloid leukemia cell line KU812 showed an antitumor activity at micromolar concentrations. As a result, compound 1 represents a promising lead for the design of novel anticancer targeted therapies.

A highly selective fluorescent chemosensor for Mg2+ based on a diarylethene with a quinoxaline unit

A new fluorescent probe 1O was synthesized through linking diarylethene and Quinoxaline-2-hydraqzide group, probe 1O showed a selective “off-on” fluorescent response toward Mg2+. In the presence of Mg2+, the probe 1O displayed a distinct change of fluorescence color, from dark to green, the fluorescence intensity increased 6.8-fold, and meanwhile, emission peak has a significant blue shift, which was shifted from 524 nm to 518 nm. Then, on account of the fluorescence properties of compound 1O, we designed a logic gate. On top of that, probe 1O also can be successfully used to monitor Mg2+ of the actual water samples.

3-Arylamino-quinoxaline-2-carboxamides inhibit the PI3K/Akt/mTOR signaling pathways to activate P53 and induce apoptosis

Thirty-eight new 3-arylaminoquinoxaline-2-carboxamide derivatives were in silico designed, synthesized and their cytotoxicity against five human cancer cell lines and one normal cells WI-38 were evaluated. Molecular mechanism studies indicated that N-(3-A

2-(omega-dialkylamino)aminoalkyl-3-aryloxazolequinoxaline compounds as well as preparation method and application thereof

The invention discloses 2-(omega-dialkylamino)aminoalkyl-3-aryloxazolequinoxaline compounds as well as a preparation method and application thereof, and specially relates to a pharmaceutical composition containing the compounds, and an application in preparation of antitumor and topoisomerase I inhibiting drugs. The compounds disclosed by the invention have a good inhibitory effect on topoisomerase I, and exhibit good antitumor effects in vitro and in vivo.