1204142-46-0Relevant academic research and scientific papers
Trimethylchlorosilane and silicon tetrachloride in two novel methodologies for the efficient and mild aldol addition of β-keto esters and malonates to aldehydes
Massa, Antonio,Roscigno, Ada,De Caprariis, Paolo,Filosa, Rosanna,Di Mola, Antonia
supporting information; experimental part, p. 3348 - 3354 (2011/02/23)
Efficient and mild aldol additions of β-keto esters and malonates to aldehydes are described using two novel protocols in the presence of silicon tetrachloride and trimethylchlorosilane, respectively. Scope and limitations of the methods have been discuss
Synthesis of β-hydroxymalonates: the direct aldol addition of malonates to aldehydes in the presence of SiCl4 and i-Pr2EtN
Massa, Antonio,Scettri, Arrigo,Filosa, Rosanna,Capozzolo, Laura
supporting information; experimental part, p. 7318 - 7321 (2010/02/28)
The direct aldol addition of malonates to aromatic, hetero-aromatic and unsaturated aldehydes leading to β-hydroxymalonates is described. The stability of these products, the trimethyl silyl protection of the hydroxyl group as well as the role of both SiC
