1204221-60-2

Upstream product

• 108-95-2 phenol 
• 2555-49-9 phenoxyacetic acid ethyl ester 
• 864070-18-8 4-(5-bromo-2-chlorobenzyl)phenol 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 1204221-70-4 (3R,4S,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxy(ethoxy-2,2-d2))benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol 
• 1204221-72-6 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxy(ethoxy-2,2-d2))benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 
• 1204221-64-6 4-bromo-1-chloro-2-(4-(2-(1-ethoxyethoxy)ethoxy-2,2-d2)-benzyl)benzene 
• 1204221-68-0 4-bromo-1-chloro-2-(4-(2-cyclopropoxy(ethoxy-2,2-d2))-benzyl)benzene 
• 1204221-66-8 4-bromo-1-chloro-2-(4-(2-(vinyloxy)ethoxy-2,2-d2)-benzyl)benzene 

Relevant academic research and scientific papers

A novel C - aryl glucoside SGLT2 inhibitor

The invention discloses a new C-aryl glycosidase SGLT2 (sodium glucose transporter type-2) inhibitor, relates to the field of medicines associated with diabetes, and in particular relates to a new C-aryl glycosidase derivative shown as the general formula (I), a preparation method thereof, compositions thereof, and use thereof in preparing hypoglycemic drugs. The C-aryl glucoside derivative has excellent effect of promoting urine discharge and in-vivo hypoglycemic activity, and compounds with equal or better in-vivo hypoglycemic activity than that of dapagliflozin are screened out, and can be used for the prevention or treatment of diabetes.

Design, Synthesis and in vivo Evaluation of Novel C-Aryl Glucosides as Potent Sodium-Dependent Glucose Cotransporters Inhibitors for the Treatment of Diabetes

A series of novel C-aryl glucosides with substituents at the 3′-position or cyclization at 3′, 4′-positions of the distal aryl ring were designed and synthesized, which might decrease the oxidative metabolism of dapagliflozin. Preliminary evaluation for hypoglycemic effect and the risk of hypoglycemia were carried out both in normal and in streptozotocin-induced diabetic mice. Among the synthesized compounds, compound 19a exerted potency-similarity with dapagliflozin and triggered the hypoglycemic effect in a dose-dependent manner. Besides, compound 19a, even at the high dose of 10 mg/kg, revealed a low risk of hypoglycemia. In further studies, 19a exhibited sustained antihyperglycemic effect without particular side-effects in 30-day chronic diabetic mice studies. Moreover, histological changes in the pancreas of diabetic mice indicated 19a might protect pancreatic β-cell from apoptosis by reducing the damage of glucotoxicity. All of these results demonstrated that compound 19a, with excellent in vivo pharmacological activity and safety profile, was considered to be a promising drug candidate for the treatment of diabetes mellitus.

DEUTERATED BENZYLBENZENE DERIVATIVES AND METHODS OF USE

Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by SGLT inhibition.