1204405-68-4

Basic information

• Product Name: 2-Boc-2,6-diazabicyclo[3.2.0]heptane
• Synonyms: 2-Boc-2,6-diazabicyclo[3.2.0]heptane;tert-Butyl 2,6-diazabicyclo[3.2.0]heptane-2-carboxylate;2,6-Diaza-bicyclo[3.2.0]heptane-2-carboxylic acid tert-butyl ester
• CAS NO: 1204405-68-4
• Molecular Formula: C10H18N2O2
• Molecular Weight: 198.26212
• Mol File: 1204405-68-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Boc-2,6-diazabicyclo[3.2.0]heptane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Boc-2,6-diazabicyclo[3.2.0]heptane(1204405-68-4)
• EPA Substance Registry System: 2-Boc-2,6-diazabicyclo[3.2.0]heptane(1204405-68-4)

Safety Data

• Hazardous Substances Data: 1204405-68-4(Hazardous Substances Data)

Usage

Uses

2-Boc-2,6-diazabicyclo[3.2.0]heptane is a useful reagent for the preparation of pyrimidine derivatives as KRas G12C inhibitors for treatment of KRas-mediated diseases.

Upstream product

• 187039-57-2 (2S,3S)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid 
• 17342-08-4 (S)-Pyroglutaminol 
• 309962-74-1 tert-butyl (2R,3S)-3-((methylsulfonyl)oxy)-2-(((methylsulfonyl)oxy)methyl)pyrrolidine-1-carboxylate 
• 156129-72-5 (2R,3S)-tert-butyl 3-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 121686-87-1 (2R,3S)-N-benzyl-3-hydroxy-2-hydroxymethylpyrrolidine 
• 1820583-17-2 (7aS)-3-phenyltetrahydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one 
• 309962-75-2 rac-tert-butyl (1R,5R)-7-benzyl-4,7-diazabicyclo[3.2.0]heptane-4-carboxylate 

Downstream Products

• 309962-75-2 rac-tert-butyl (1R,5R)-7-benzyl-4,7-diazabicyclo[3.2.0]heptane-4-carboxylate 
• 370880-27-6 2,6-diazabicylo[3.2.0]heptane-2-carboxylic acid tert-butyl ester 
• 1408075-03-5 C₁₀H₁₈N₂O₂ 
• 1408075-03-5 tert-butyl (1S,5S)-2,6-diazabicyclo[3.2.0]heptane-6-carboxylate 

Relevant articles and documents

QUINAZOLINE COMPOUNDS, PREPARATION METHODS AND USES THEREOF

Provided herein are novel compounds, for example, compounds having a Formula (I), Formula (II), or Formula (III), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRAS G12D in a cancer cell, and/or in treating various cancer such as pancreatic cancer, colorectal cancer, lung cancer or endometrial cancer.

Substituted diazabicycloalkane derivatives

Compounds of formula (I) [in-line-formulae]Z-Ar1—Ar2??(I) [/in-line-formulae] wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.