2-Boc-2,6-diazabicyclo[3.2.0]heptane

Base Information

Chemical Name:2-Boc-2,6-diazabicyclo[3.2.0]heptane
CAS No.:1204405-68-4
Molecular Formula:C10H18N2O2
Molecular Weight:198.26212
Hs Code.:2933990090
Mol file:1204405-68-4.mol

Synonyms:2-Boc-2,6-diazabicyclo[3.2.0]heptane;tert-Butyl 2,6-diazabicyclo[3.2.0]heptane-2-carboxylate;2,6-Diaza-bicyclo[3.2.0]heptane-2-carboxylic acid tert-butyl ester

Suppliers and Price of 2-Boc-2,6-diazabicyclo[3.2.0]heptane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Boc-2,6-diazabicyclo[3.2.0]heptane
100mg
$ 500.00

Synthonix
2-Boc-2,6-diazabicyclo[3.2.0]heptane 97.0%
5g
$ 3930.00

Synthonix
2-Boc-2,6-diazabicyclo[3.2.0]heptane 97.0%
1g
$ 1280.00

SynQuest Laboratories
2-Boc-2,6-diazabicyclo[3.2.0]heptane
250 mg
$ 490.00

Matrix Scientific
2-Boc-2,6-diazabicyclo[3.2.0]heptane
1g
$ 1565.00

J&W Pharmlab
2,6-Diaza-bicyclo[3.2.0]heptane-2-carboxylicacidtert-butylester 96%
100mg
$ 325.00

J&W Pharmlab
2,6-Diaza-bicyclo[3.2.0]heptane-2-carboxylicacidtert-butylester 96%
50mg
$ 212.00

J&W Pharmlab
2,6-Diaza-bicyclo[3.2.0]heptane-2-carboxylicacidtert-butylester 96%
500mg
$ 998.00

J&W Pharmlab
2,6-Diaza-bicyclo[3.2.0]heptane-2-carboxylicacidtert-butylester 96%
250mg
$ 549.00

J&W Pharmlab
2,6-Diaza-bicyclo[3.2.0]heptane-2-carboxylicacidtert-butylester 96%
5g
$ 6880.00

Total 8 raw suppliers

Chemical Property of 2-Boc-2,6-diazabicyclo[3.2.0]heptane

Chemical Property:

PSA：41.57000
LogP:1.23430

Purity/Quality:

99%, ^*data from raw suppliers

2-Boc-2,6-diazabicyclo[3.2.0]heptane ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2-Boc-2,6-diazabicyclo[3.2.0]heptane is a useful reagent for the preparation of pyrimidine derivatives as KRas G12C inhibitors for treatment of KRas-mediated diseases.

Technology Process of 2-Boc-2,6-diazabicyclo[3.2.0]heptane

There total 11 articles about 2-Boc-2,6-diazabicyclo[3.2.0]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 309962-75-2
rac-tert-butyl (1R,5R)-7-benzyl-4,7-diazabicyclo[3.2.0]heptane-4-carboxylate

: 370880-27-6,1204405-68-4
2,6-diazabicylo[3.2.0]heptane-2-carboxylic acid tert-butyl ester

Guidance literature:: palladium-carbon; In ethanol;

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 370880-27-6,1204405-68-4
2,6-diazabicylo[3.2.0]heptane-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: toluene-4-sulfonic acid / toluene / 48 h / 125 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -65 °C

2.2: 1 h / -65 °C

2.3: 3 h / 0 - 25 °C

3.1: potassium carbonate; tert.-butylhydroperoxide / N,N-dimethyl-formamide / 0.5 h / 25 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

4.1: acetic acid; sodium tetrahydroborate; diphenyl diselenide / ethanol / 0.5 h / 25 °C

5.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 70 °C

6.1: palladium on activated charcoal; hydrogen / methanol / 16 h / 40 °C / 2585.81 Torr

7.1: triethylamine / dichloromethane / 4 h / 0 °C

8.1: toluene / 16 h / 110 °C

9.1: palladium on activated charcoal; hydrogen / ethanol / 36 h / 60 °C / 2585.81 Torr / Inert atmosphere

With tert.-butylhydroperoxide; sodium tetrahydroborate; dimethylsulfide borane complex; diphenyl diselenide; palladium on activated charcoal; hydrogen; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 156129-72-5
(2R,3S)-tert-butyl 3-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

: 370880-27-6,1204405-68-4
2,6-diazabicylo[3.2.0]heptane-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 4 h / 0 °C

2: toluene / 16 h / 110 °C

3: palladium on activated charcoal; hydrogen / ethanol / 36 h / 60 °C / 2585.81 Torr / Inert atmosphere

With palladium on activated charcoal; hydrogen; triethylamine; In ethanol; dichloromethane; toluene;