1204502-33-9Relevant academic research and scientific papers
Selective demethylation and debenzylation of aryl ethers by magnesium iodide under solvent-free conditions and its application to the total synthesis of natural products
Bao, Kai,Fan, Aixue,Dai, Yi,Zhang, Liang,Zhang, Weige,Cheng, Maosheng,Yao, Xinsheng
experimental part, p. 5084 - 5090 (2010/04/03)
An efficient selective demethylation and debenzylation method for aryl methyl/benzyl ethers using magnesium iodide under solvent-free conditions has been developed and applied to the synthesis of natural flavone and biphenyl glycosides. A variety of functional groups including glycoside were tolerated under the reaction conditions. Experimental results indicated that the removal of an O-benzyl group was easier than that of an O-methyl group, regardless of wherever they were meta or para to the carbonyl. Thus selective debenzylation can be achieved for substrates bearing both benzyloxy and methoxy groups.
