1204603-42-8

Basic information

• Product Name: (7R,8aS)-tert-butyl 7-hydroxyhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate
• Synonyms: (7R,8aS)-tert-butyl 7-hydroxyhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate
• CAS NO: 1204603-42-8
• Molecular Weight: 242.318
• Mol File: 1204603-42-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (7R,8aS)-tert-butyl 7-hydroxyhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (7R,8aS)-tert-butyl 7-hydroxyhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate(1204603-42-8)
• EPA Substance Registry System: (7R,8aS)-tert-butyl 7-hydroxyhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate(1204603-42-8)

Safety Data

• Hazardous Substances Data: 1204603-42-8(Hazardous Substances Data)

Usage

General Description

The chemical compound "(7R,8aS)-tert-butyl 7-hydroxyhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate" is a complex organic molecule with a molecular formula of C11H19NO3. It is classified as a carboxylate ester and is composed of a tert-butyl group, a hydroxyhexahydropyrrolo ring, a pyrazine ring, and a carboxylic acid ester functional group. (7R,8aS)-tert-butyl 7-hydroxyhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate is synthetically derived and has potential applications in pharmaceuticals or as a building block for organic synthesis. Its specific properties, uses, and potential effects on biological systems would need to be further investigated.

Upstream product

• 13726-69-7 (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 
• 51-35-4 4R-4-hydroxyproline 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 132715-08-3 (6S,8R)-4-benzyl-8-hydroxy-1,4-diazabicyclo<4.3.0>nonane 
• 132714-97-7 (7R,8aS)-2-benzyl-7-hydroxyhexahydropyrrolo[1,2-a]pyrazine-1,4-dione 
• 132715-17-4 (2S,4R)-methyl 1-(2-chloroacetyl)-4-hydroxypyrrolidine-2-carboxylate 
• 1161000-19-6 (7R,8AS)-7-hydroxy-1,2,3,4,6,7,8,8a-octahydro-pyrrolo[1,2-a]-pyrazine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1429295-52-2 (7R,8aS)-7-[(5-chloropyridin-2-yl)oxy]-2-[3-(trifluoromethyl)benzyl]octahydropyrrolo[1,2-a]pyrazine 
• 1429296-13-8 1-[(7R,8aS)-7-{[5-(prop-1-en-2-yl)pyrazin-2-yl]oxy}hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-[3-(trifluoromethyl)phenyl]ethanone 
• 1429296-21-8 1-[(7R,8aS)-7-[(5-isopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-[3-(trifluoromethyl)phenyl]ethanone 
• 1429295-25-9 [(7R,8aS)-7-[(5-chloropyridin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl][3-(trifluoromethyl)phenyl]methanone 
• 1429199-52-9 (7R,8aS)-7-{[5-(1-methylcyclopropyl)pyrazin-2-yl]oxy}-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydropyrrolo[1,2-a]pyrazine 
• 1429199-72-3 (7R,8aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}-7-{[5-(trifluoromethyl)-pyridin-2-yl]oxy}octahydropyrrolo[1,2-a]pyrazine 

Relevant articles and documents

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula (I) (Formula (I)) including pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS

The present application relates to: (a) compounds of Formula (I): (I), and salts thereof, wherein Z1, Z2, Z3, Z4, R1, R2, and R3 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel inhibitors.