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1204669-67-9

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  • 1,2,4-Oxadiazol-5(4H)-one, 3-[4-[(2-aminoethyl)amino]-1,2,5-oxadiazol-3-yl]-4-(3-bromo-4-fluorophenyl)-, hydrochloride (1:1)

    Cas No: 1204669-67-9

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1204669-67-9 Usage

General Description

1,2,4-Oxadiazol-5(4H)-one, 3-[4-[(2-aminoethyl)amino]-1,2,5-oxadiazol-3-yl]-4-(3-bromo-4-fluorophenyl)-, hydrochloride (1:1) is a complex organic compound containing bromine, fluorine, and hydrochloride elements. This chemical compound is characterized by three chemical groups: oxadiazol, a nitrogenous heterocyclic compound, an aminoethylamino group, and a bromo-fluorophenyl group, attached in a specific structural form, which could potentially contribute to its unique chemical behavior. The compound exists in a one-to-one ratio with hydrochloride, suggesting it may exist as a salt in its solid or dissolved states. The details about its physical properties, uses, toxicity, or its role in any chemical reactions are not specified, thus requiring further research or specific context.

Check Digit Verification of cas no

The CAS Registry Mumber 1204669-67-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,4,6,6 and 9 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1204669-67:
(9*1)+(8*2)+(7*0)+(6*4)+(5*6)+(4*6)+(3*9)+(2*6)+(1*7)=149
149 % 10 = 9
So 1204669-67-9 is a valid CAS Registry Number.

1204669-67-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-{4-[(2-aminoethyl)amino]-1,2,5-oxadiazol-3-yl}-4-(3-bromo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one hydrochloride

1.2 Other means of identification

Product number -
Other names 3-{4-[(2-aminoethyl)amino]-1,2,5-oxadiazol-3-yl}-4-(3-bromo-4-fluorophenyl)-1.2.4-oxadiazol-5(4H)-one hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:1204669-67-9 SDS

1204669-67-9Relevant articles and documents

A kind of IDO inhibitor and use thereof

-

, (2019/07/11)

The embodiment of the invention provides general formula (I) compound or its pharmaceutically acceptable salts, stereoisomers, a tautomeric form each other, polymorphs, solvate, prodrug, metabolite or isotope derivatives, wherein the substituents R1

Discovery of phosphonamidate IDO1 inhibitors for the treatment of non-small cell lung cancer

Du, Qianming,Feng, Xi,Wang, Yinuo,Xu, Xi,Zhang, Yan,Qu, Xinliang,Li, Zhiyu,Bian, Jinlei

, (2019/08/26)

Targeting indoleamine 2,3-dioxygenase 1 (IDO1) has been identified as an attractive approach for the development of cancer immunotherapy. In this study, a series of phosphonamidate ester containing compounds were designed, synthesized and evaluated for their inhibitory activities against IDO1. Among them, compounds 16, 17, and 26 with good IDO1 inhibitory (HeLa IDO1 IC50 = 10–21 nM, hIDO1 IC50 = 78–121 nM) activities were selected for further investigation and showed good physicochemical properties. Furthermore, based on comparable PK profile and excellent IDO2/TDO inhibitory potency, representative compound 16 was selected for further bio-evaluation and characterized with good efficacy in suppressing lung metastasis (77% inhibition rate) of Lewis cells in vivo. Thus, compound 16 could be a potential and efficacious agent for further evaluation.

INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology

Yue, Eddy W.,Sparks, Richard,Polam, Padmaja,Modi, Dilip,Douty, Brent,Wayland, Brian,Glass, Brian,Takvorian, Amy,Glenn, Joseph,Zhu, Wenyu,Bower, Michael,Liu, Xiangdong,Leffet, Lynn,Wang, Qian,Bowman, Kevin J.,Hansbury, Michael J.,Wei, Min,Li, Yanlong,Wynn, Richard,Burn, Timothy C.,Koblish, Holly K.,Fridman, Jordan S.,Emm, Tom,Scherle, Peggy A.,Metcalf, Brian,Combs, Andrew P.

, p. 486 - 491 (2017/05/19)

A data-centric medicinal chemistry approach led to the invention of a potent and selective IDO1 inhibitor 4f, INCB24360 (epacadostat). The molecular structure of INCB24360 contains several previously unknown or underutilized functional groups in drug subs

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