1205-86-3

Basic information

• Product Name: Benzenemethanamine, N-[(1,1-dimethylethyl)carbonimidoyl]-
• CAS NO: 1205-86-3
• Molecular Formula: C12H16N2
• Molecular Weight: 188.272
• Mol File: 1205-86-3.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Benzenemethanamine, N-[(1,1-dimethylethyl)carbonimidoyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, N-[(1,1-dimethylethyl)carbonimidoyl]-(1205-86-3)
• EPA Substance Registry System: Benzenemethanamine, N-[(1,1-dimethylethyl)carbonimidoyl]-(1205-86-3)

Safety Data

• Hazardous Substances Data: 1205-86-3(Hazardous Substances Data)

Upstream product

• 1193913-68-6 C₆H₁₂ClNO₃S 
• 100-46-9 benzylamine 
• 1609-86-5 Tert-butyl isocyanate 
• 190712-80-2 TiCl₂(N-tert-butylimido)bischlorobis(pyridine)titanium(IV) 
• 3173-56-6 benzyl isothiocyanate 
• 100-39-0 benzyl bromide 
• 119072-55-8 tert-butylisonitrile 
• 622-79-7 benzyl azide 
• 13686-33-4 t-butyl azide 
• 88333-03-3 Benzyl isocyanide 
• 590-42-1 tert-butyl isothiocyanate 
• 14327-01-6 1-t-butyl-3-benzylthiocarbamide 
• 124316-00-3 1-<<(Triphenylphosphoranylidene)amino>methyl>benzotriazole 
• 91905-62-3 N-Benzyl-N'-tert-butyl-isothioharnstoff-S-methylaether 

Downstream Products

• 556065-18-0 [(η5-C5Me5)ZrMe2[N(CH2C6H5)C(Me)N(t-Bu)] 
• 1118749-85-1 1-benzyl-3-tert-butyl-5-phenyl-imidazolidine-2,4-dione 
• 15942-15-1 N-benzyl-N'-tert-butyl urea 
• 1415958-94-9 1-benzyl-3-tert-butyl-5-ethylimidazolidine-2,4-dione 
• 1415959-12-4 N-(benzylcarbamoyl)-2-bromo-N-tert-butylbutanamide 
• 1415958-95-0 C₁₆H₂₂N₂O₂ 
• 1415959-00-0 1-benzyl-3-tert-butyl-1,3-diazaspiro[4.5]decane-2,4-dione 
• 1118749-87-3 1-benzyl-3-tert-butyl-5-(4-fluorophenyl)-imidazolidine-2,4-dione 
• 1428967-47-8 C₂₈H₃₇N₃O₆ 
• 1428966-95-3 C₂₈H₃₇N₃O₆ 
• 1607430-80-7 (2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-[(S)-2-(1-benzyl-3-tert-butylureido)-4-benzyloxy-4-oxobutanamido]tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1607430-62-5 (2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-[(R)-2-(1-benzyl-3-tert-butylureido)-4-benzyloxy-4-oxobutanamido]tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1607430-88-5 C₂₃H₂₆N₂O₄ 

Relevant articles and documents

Gram Scalable Method to Synthesize Biscarbodiimides and Asymmetric Monocarbodiimides: A Platform to Access an Array of Phosphaguanidines, Amidines, and Guanidines

A mild, broadly functional group tolerant methodology has been developed to access a variety of mono- and bis-carbodiimides in good yield and high purity on multigram scale. Direct addition into these versatile motifs facilitated the rapid synthesis of a library of novel amidinines, guanidines, and phosphaguandines.

Multicomponent Approach to Libraries of Substituted Dihydroorotic Acid Amides

A process featuring a sequential multicomponent reaction followed by a regioselective postcyclization strategy was implemented for the facile synthesis of N,N′-disubstituted dihydroorotic acid amides under mild conditions. We obtained, for the first time, a library of 29 derivatives, encompassing 19 Nα-substituted-N4-dihydroorotyl-4-aminophenylalanine derivatives, a key residue of gonadotropin-releasing hormone antagonist Degarelix. The corresponding products were prepared from easily accessible starting materials in good to excellent yields with broad substrate scope.

Palladium-catalyzed cross-coupling reaction of azides with isocyanides

An efficient palladium-catalyzed cross-coupling reaction of azides with isocyanides is developed, providing a general synthetic route to unsymmetric carbodiimides with excellent yields. This method shows a broad substrate scope, including not only aryl azides, but also unactivated benzyl and alkyl azides. Furthermore, from readily available substrates, Pd-catalyzed coupling with a tandem amine insertion cascade to obtain unsymmetric trisubstituted guanidines has been achieved in a one-pot fashion.