120552-01-4 Usage
Description
2-(4-Nitrophenoxy)butanoic acid is a chemical compound with the molecular formula C10H11NO6. It is a derivative of butanoic acid, featuring a nitrophenyl group attached to the second carbon atom. 2-(4-NITROPHENOXY)BUTANOIC ACID is known for its potential biological activity and is widely utilized in organic synthesis and pharmaceutical research.
Uses
Used in Pharmaceutical Research:
2-(4-Nitrophenoxy)butanoic acid is used as a research compound for its potential biological activity, contributing to the development of new pharmaceutical drugs. Its unique structure allows for exploration in various therapeutic areas.
Used in Agrochemicals:
In the agrochemical industry, 2-(4-Nitrophenoxy)butanoic acid is used as a precursor for the synthesis of various agrochemicals, aiding in the production of effective crop protection products.
Used in Organic Synthesis:
2-(4-Nitrophenoxy)butanoic acid is employed as an intermediate in the synthesis of a range of organic compounds, including dyes and pigments, due to its versatile chemical properties.
Used in Dye and Pigment Production:
2-(4-NITROPHENOXY)BUTANOIC ACID is used as a key component in the production of dyes and pigments, where its chemical structure contributes to the color and stability of the final products.
Check Digit Verification of cas no
The CAS Registry Mumber 120552-01-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,5,5 and 2 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 120552-01:
(8*1)+(7*2)+(6*0)+(5*5)+(4*5)+(3*2)+(2*0)+(1*1)=74
74 % 10 = 4
So 120552-01-4 is a valid CAS Registry Number.
120552-01-4Relevant articles and documents
Structure-based modification of carbonyl-diphenylpyrimidines (Car-DPPYs) as a novel focal adhesion kinase (FAK) inhibitor against various stubborn cancer cells
Wang, Luhong,Ai, Min,Yu, Jiawen,Jin, Lingling,Wang, Changyuan,Liu, Zhihao,Shu, Xiaohong,Tang, Zeyao,Liu, Kexin,Luo, Hui,Guan, Wenshun,Sun, Xiuli,Ma, Xiaodong
, p. 154 - 162 (2019/04/13)
A family of carbonyl-substituted diphenylpyrimidine derivatives (Car-DPPYs) with strong activity against focal adhesion kinase (FAK), were described in this manuscript. Among them, compounds 7a (IC50 = 5.17 nM) and 7f (IC50 = 2.58 nM) displayed equal anti-FAK enzymatic activity to the lead compound TAE226 (6.79 nM). In particular, compound 7a also exhibited strong antiproliferative activity against several stubborn cancer cells, including AsPC-1 cells (IC50 = 0.105 μM), BxPC-3 cells (IC50 = 0.090 μM), and MCF-7/ADR cells (IC50 = 0.59 μM). Additionally, compound 7a also showed great antitumor efficacy in vivo via aAsPC-1 cancer Xenograft mouse model. The preliminary mechanism study by Western blot analysis revealed that 7a repressed FAK phosphorylation in AsPC cancer cells. Taken together, the results indicate that compound 7a may serve as a promising preclinical candidate for treatment of stubborn cancers.
