86464-92-8

Basic information

• Product Name: Butanoyl chloride, 2-(4-nitrophenoxy)-
• Synonyms: 2-(4-nitrophenoxy)butyryl chloride;2-(4-nitrophenoxy)butanoyl chloride;butanoyl chloride, 2-(4-nitrophenoxy)-
• CAS NO: 86464-92-8
• Molecular Formula: C₁₀H₁₀ClNO₄
• Molecular Weight: 243.64
• Mol File: 86464-92-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Butanoyl chloride, 2-(4-nitrophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoyl chloride, 2-(4-nitrophenoxy)-(86464-92-8)
• EPA Substance Registry System: Butanoyl chloride, 2-(4-nitrophenoxy)-(86464-92-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 86464-92-8(Hazardous Substances Data)

Upstream product

• 120552-01-4 2-(4-nitro-phenoxy)-butyric acid 
• 100-02-7 4-nitro-phenol 

Relevant articles and documents

Structure-based modification of carbonyl-diphenylpyrimidines (Car-DPPYs) as a novel focal adhesion kinase (FAK) inhibitor against various stubborn cancer cells

A family of carbonyl-substituted diphenylpyrimidine derivatives (Car-DPPYs) with strong activity against focal adhesion kinase (FAK), were described in this manuscript. Among them, compounds 7a (IC50 = 5.17 nM) and 7f (IC50 = 2.58 nM) displayed equal anti-FAK enzymatic activity to the lead compound TAE226 (6.79 nM). In particular, compound 7a also exhibited strong antiproliferative activity against several stubborn cancer cells, including AsPC-1 cells (IC50 = 0.105 μM), BxPC-3 cells (IC50 = 0.090 μM), and MCF-7/ADR cells (IC50 = 0.59 μM). Additionally, compound 7a also showed great antitumor efficacy in vivo via aAsPC-1 cancer Xenograft mouse model. The preliminary mechanism study by Western blot analysis revealed that 7a repressed FAK phosphorylation in AsPC cancer cells. Taken together, the results indicate that compound 7a may serve as a promising preclinical candidate for treatment of stubborn cancers.