1205638-74-9

Basic information

• Product Name: 2-(4-fluorophenyl)-2-methylpropanal
• Synonyms: 2-(4-fluorophenyl)-2-methylpropanal
• CAS NO: 1205638-74-9
• Molecular Weight: 166.195
• Mol File: 1205638-74-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)-2-methylpropanal(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-2-methylpropanal(1205638-74-9)
• EPA Substance Registry System: 2-(4-fluorophenyl)-2-methylpropanal(1205638-74-9)

Safety Data

• Hazardous Substances Data: 1205638-74-9(Hazardous Substances Data)

Usage

General Description

2-(4-fluorophenyl)-2-methylpropanal is a chemical compound with the molecular formula C10H11FO. It is a colorless liquid with a fruity odor, and it is commonly used as a flavoring agent in the food industry. 2-(4-fluorophenyl)-2-methylpropanal is also used in the production of pharmaceuticals and as a building block in organic synthesis. 2-(4-fluorophenyl)-2-methylpropanal is considered to be relatively safe, with low toxicity and no known carcinogenic effects. However, it should be handled with care and in accordance with safety guidelines due to its potential irritant effects on the skin and eyes.

Upstream product

• 459-22-3 4-fluorophenylacetonitrile 
• 74-88-4 methyl iodide 
• 93748-19-7 2-(4-fluorophenyl)-2-methylpropanoic acid 
• 703-10-6 2,2-Dimethyl-2-(4-fluorophenyl)ethanol 

Downstream Products

• 1242272-80-5 1-fluoro-4-(2-methylbut-3-yn-2-yl)benzene 
• 1205638-76-1 (E)-4-(4-fluoro-phenyl)-4-methyl-pent-2-enoic acid ethyl ester 

Relevant articles and documents

Intermolecular Reductive Couplings of Arylidene Malonates via Lewis Acid/Photoredox Cooperative Catalysis

A cooperative Lewis acid/photocatalytic reduction of arylidene malonates yields a versatile radical anion species. This intermediate preferentially undergoes intermolecular radical-radical coupling reactions, and not the conjugate addition-dimerization reactivity typically observed in the single-electron reduction of conjugate acceptors. Reported here is the development of this open-shell species in intermolecular radical-radical cross couplings, radical dimerizations, and transfer hydrogenations. This reactivity underscores the enabling modularity of cooperative catalysis and demonstrates the utility of stabilized enoate-derived radical anions in intermolecular bond forming reactions.

Dual Gold Catalysis: Synthesis of Fluorene Derivatives from Diynes

1,5-Diyne systems bearing one terminal and one benzyl- or allyl-substituted alkyne attached to an aromatic backbone were converted in the presence of a gold catalyst. In a dual gold-catalyzed process, gold vinylidenes are formed that selectively undergo formal CH insertion into the C(sp2)–H bond of the offered unsaturated systems. If H atoms are present in the propargylic position, a subsequent isomerization to the aromatic system takes place leading to 9H-fluorene and 11H-benzo[b]fluorene derivatives as final products. In the case of a quaternary carbon in the propargylic position no further aromatization is observed and 10H-benzo[b]fluorene derivatives are obtained in high yield. (Figure presented.).

INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS

Compound of formula (I) are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-mediated diseases such as asthma.