1242272-80-5

Usage

Functional groups

Fluorine atom, aromatic ring, methylbutynyl group

Structural features

a. Fluorine atom attached to the first carbon of the benzene ring
b. Methylbutynyl group attached to the fourth carbon of the benzene ring
c. Methyl group on the butynyl chain

Aromatic compound

Yes

Fluorinated compound

Yes

Applications

a. Organic synthesis
b. Building block for complex organic molecules
c. Pharmaceutical industry
d. Agrochemical industry
e. Fine chemicals and materials production
f. Research and development in chemical and pharmaceutical industries

Physical state

Likely a liquid or solid at room temperature (based on molecular size and complexity)

Solubility

Likely soluble in organic solvents such as ethanol, acetone, or dichloromethane

Stability

Stable under normal conditions, but may be sensitive to heat, light, or strong acids/bases

Reactivity

May undergo reactions such as electrophilic aromatic substitution, nucleophilic substitution, and free radical reactions due to the presence of the aromatic ring and fluorine atom.

Upstream product

• 1017409-06-1 3-(4-Fluorophenyl)-3-methyl-2-butanone 
• 10026-13-8 phosphorus pentachloride 
• 15877-26-6 4-chloromethyl-Δ³-chromene 
• 74-89-5 methylamine 
• 67-56-1 methanol 
• 1205638-74-9 2-(4-fluorophenyl)-2-methylpropanal 
• 90965-06-3 dimethyl 1-(1-diazo-2-oxopropyl)phosphonate 

Downstream Products

• 1242272-81-6 ethyl (4-fluoro-7-{5-[2-(4-fluorophenyl)propan-2-yl]-1H-1,2,3-triazoI-1-yl}-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate 

Relevant academic research and scientific papers

Dual Gold Catalysis: Synthesis of Fluorene Derivatives from Diynes

1,5-Diyne systems bearing one terminal and one benzyl- or allyl-substituted alkyne attached to an aromatic backbone were converted in the presence of a gold catalyst. In a dual gold-catalyzed process, gold vinylidenes are formed that selectively undergo formal CH insertion into the C(sp2)–H bond of the offered unsaturated systems. If H atoms are present in the propargylic position, a subsequent isomerization to the aromatic system takes place leading to 9H-fluorene and 11H-benzo[b]fluorene derivatives as final products. In the case of a quaternary carbon in the propargylic position no further aromatization is observed and 10H-benzo[b]fluorene derivatives are obtained in high yield. (Figure presented.).

INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS

Compound of formula (I) are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-mediated diseases such as asthma.

Anti-fungal homopropargylamines, compositions, and method of use therefor

The invention relates to novel homopropargylamines of formula I STR1 wherein n is 2 or 3, R1 is a group of formula IIa, IIb or IIc STR2 in which R6 and R7 independently are H, halogen, CF3, lower alkyl or lower