1205676-44-3 Usage
Description
(1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid hydrochloride, also known as (1R,3aS,6aS)-bicyclo[3.1.0]hexane-2-carboxylic acid hydrochloride, is a chemical compound derived from cyclopentane, featuring a cyclohexane ring fused to a cyclopentane ring. (1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid hydrochloride is characterized by its unique stereochemistry and serves as a versatile building block in organic synthesis and medicinal chemistry.
Uses
Used in Organic Synthesis:
(1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid hydrochloride is used as a building block in organic synthesis for the creation of various bioactive compounds and pharmaceuticals. Its unique structure and functional groups enable the formation of diverse chemical entities, contributing to the development of novel molecules with potential applications in various fields.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid hydrochloride is utilized as a precursor for the preparation of functionalized cyclopentane derivatives. These derivatives possess potential therapeutic properties and can be further modified to enhance their bioactivity, selectivity, and pharmacokinetic profiles, ultimately leading to the discovery of new drugs and therapeutic agents.
Used in Drug Development:
(1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid hydrochloride plays a crucial role in drug development as a valuable compound in organic chemistry research. Its ability to serve as a precursor for the synthesis of various cyclopentane derivatives makes it an essential component in the design and development of new pharmaceuticals, targeting a wide range of diseases and medical conditions.
Used in Research and Development of Cyclopentane Derivatives:
(1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid hydrochloride is also used in the research and development of cyclopentane derivatives, which have potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science. The exploration of its chemical properties and reactivity allows scientists to uncover new ways to synthesize and functionalize cyclopentane-based molecules, expanding the scope of their applications and potential benefits.
Check Digit Verification of cas no
The CAS Registry Mumber 1205676-44-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,5,6,7 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1205676-44:
(9*1)+(8*2)+(7*0)+(6*5)+(5*6)+(4*7)+(3*6)+(2*4)+(1*4)=143
143 % 10 = 3
So 1205676-44-3 is a valid CAS Registry Number.
1205676-44-3Relevant articles and documents
Preparation method for bicyclic pyrrolidine intermediate of telaprevir
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Paragraph 0025; 0045, (2017/01/17)
The invention discloses a preparation method for a bicyclic pyrrolidine intermediate of telaprevir. The intermediate is (1S,3alphaR,6alphaS)-octahydrocyclopenta[c]pyrrole-1-carboxylic acid-ethyl ester hydrochloride. The preparation method comprises the following steps: (1) with 3-azabicyclo[3.3.0]octane hydrochloride as a raw material, carrying out Boc2O protection under the action of inorganic base so as to obtain an intermediate 1; (2) dissolving the intermediate 1 in an organic solvent, adding chiral organic ligand, carrying out a reaction with lithium alkyl at -70 DEG C for 2 h under the protection of nitrogen and introducing dry carbon dioxide so as to obtain an intermediate 2; and (3) adding the intermediate 2 into a saturated hydrogen chloride ethanol solution and carrying out a heating reflux reaction for 3 h so as to obtain the target compound. The preparation method provided by the invention has the advantages of short synthesis route, low cost, high product yield and optical purity and easiness in realization of large-scale production.
BIOCATALYTIC PROCESSES FOR THE PREPARATION OF SUBSTANTIALLY STEREOMERICALLY PURE FUSED BICYCLIC PROLINE COMPOUNDS
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Page/Page column 96, (2010/04/03)
The present disclosure provides substantially stereomerically pure fused bicyclic proline compounds of structural Formulae II to VII as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
