714194-68-0

Basic information

• Product Name: Octahydro-cyclopenta[c]pyrrole-1-carboxylic acid tert-butyl ester
• Synonyms: Octahydro-cyclopenta[c]pyrrole-1-carboxylic acid tert-butyl ester;(1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid tert-butyl ester;(1S,3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-carboxylic acid t-butyl ester oxalic acid salt;Cyclopenta[c]pyrrole-1-carboxylic acid, octahydro-, 1,1-diMethylethyl ester, (1S,3aR,6aS)-;(1S,3aR,6aS);-tert-Butyl octahydrocyclopenta[c]pyrrole-1-carboxylate;tert-butyl (1S,3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-carboxylate
• CAS NO: 714194-68-0
• Molecular Formula: C₁₂H₂₁NO₂
• Molecular Weight: 211
• Mol File: 714194-68-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 279℃
• Flash Point: 122℃
• Appearance: /
• Density: 1.024
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Octahydro-cyclopenta[c]pyrrole-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Octahydro-cyclopenta[c]pyrrole-1-carboxylic acid tert-butyl ester(714194-68-0)
• EPA Substance Registry System: Octahydro-cyclopenta[c]pyrrole-1-carboxylic acid tert-butyl ester(714194-68-0)

Safety Data

• Hazardous Substances Data: 714194-68-0(Hazardous Substances Data)

Usage

General Description

Octahydro-cyclopenta[c]pyrrole-1-carboxylic acid tert-butyl ester is a chemical compound that belongs to the class of cyclopentanes. It is an ester derivative of cyclopenta[c]pyrrole-1-carboxylic acid, with a tert-butyl group attached to the carboxylic acid functional group. Octahydro-cyclopenta[c]pyrrole-1-carboxylic acid tert-butyl ester is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals and agrochemicals. It has also been studied for its potential biological activities, including its role as an anti-inflammatory and analgesic agent. Overall, octahydro-cyclopenta[c]pyrrole-1-carboxylic acid tert-butyl ester is a versatile chemical with important applications in the field of medicinal and agricultural chemistry.

Upstream product

• 402960-06-9 (1S,3aR,6aS)-di-tert-butyl hexahydrocyclo-penta[c]pyrrol-1,2(1H)-dicarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1292320-79-6 (1R,2R)-2-(nitromethyl)cyclopentane-1-carbaldehyde 
• 540-88-5 acetic acid tert-butyl ester 
• 1205676-44-3 (1S,3αR,6αS)-octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride 
• 1205676-37-4 (1S,3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-carbonitrile 
• 629-11-8 1,6-hexanediol 
• 1414976-22-9 C₉H₁₅NO₄ 
• 6140-65-4 1-cyclopentene-1-carboxaldehyde 
• 1414976-37-6 C₁₉H₂₇NO₂ 
• 926276-11-1 (1S,3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-carboxylic acid 
• 115-11-7 isobutene 
• 1414976-36-5 C₁₅H₁₉NO₂ 
• 1414976-35-4 C₁₅H₁₈N₂ 

Downstream Products

• 907606-68-2 tert-butyl (1S,3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-carboxylate oxalic acid salt 
• 926276-19-9 (1S,3aR,6aS)-tert-butyl 2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylate 
• 926276-15-5 (1S,3aR,6aS)-tert-butyl 2-((S)-2-(benzyloxycarbonylamino)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylate 

Relevant articles and documents

PROCESS FOR PRODUCING ESTER COMPOUND

Compound (1) or a salt that is useful as an intermediate for the production of a medicine, an agrochemical or the like can be produced by a process including the following steps: (A) reacting an aldehyde (2) with nitromethane to produce a nitroaldehyde; (B) reacting the nitroaldehyde with an alcohol to produce a nitroacetal; (C) reducing the nitroacetal to produce an aminoacetal; (D) protecting an amino group in the aminoacetal to produce a protected aminoacetal; (E) treating the protected aminoacetal with an acid and subsequently with a base and then reacting the resultant product with a cyanating agent to produce a nitrile; (F) hydrolyzing the nitrile to produce a protected amino acid; and (G) substituting a group R5 in the protected amino acid by a hydrogen atom and protecting a carboxyl group therein.

PROCESS FOR THE PREPARATION OF PROTEASE INHIBITORS

A process for preparing enantioselectively a compound of formula (la) or (Ib) over a compound of formulas I-2—1h.

Processes and intermediates

The invention relates to compounds and processes useful for the preparation of protease inhibitors, particularly serine protease inhibitors. The protease inhibitors are useful for treatment of HCV infections.