120586-56-3

Basic information

• Product Name: Propanoic acid, 2-(hydroxyimino)-, ethyl ester, (Z)- (9CI)
• Synonyms: Propanoic acid, 2-(hydroxyimino)-, ethyl ester, (Z)- (9CI);ethyl (Z)-2-(hydroxyimino)propanoate;ethyl (2Z)-2-(hydroxyimino)propanoate
• CAS NO: 120586-56-3
• Molecular Formula: C₅H₉NO₃
• Molecular Weight: 131.12986
• Product Categories: GLYCINESCAFFOLD
• Mol File: 120586-56-3.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Propanoic acid, 2-(hydroxyimino)-, ethyl ester, (Z)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2-(hydroxyimino)-, ethyl ester, (Z)- (9CI)(120586-56-3)
• EPA Substance Registry System: Propanoic acid, 2-(hydroxyimino)-, ethyl ester, (Z)- (9CI)(120586-56-3)

Safety Data

• Hazardous Substances Data: 120586-56-3(Hazardous Substances Data)

Upstream product

• 859954-00-0 2-nitroso-propionic acid ethyl ester 
• 32116-05-5 ethyl 2-bromo-2-methyl-3-oxobutanoate 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 535-11-5 Ethyl 2-bromopropionate 
• 2531-80-8 ethyl 2-nitropropionate 
• 105-37-3 Ethyl propionate 
• 80675-53-2 1-ethoxy-1-trimethylsiloxyprop-1-ene 
• 27772-62-9 ethyl 2-formylpropionate 
• 131401-52-0 Diethyl 2-(Hydroxyimino)succinate 
• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 68-12-2 N,N-dimethyl-formamide 
• 73967-97-2 (1E)-1-ethoxy-1-(trimethylsiloxy)propene 
• 64-17-5 ethanol 
• 79894-70-5 methyl-2,2,2-trichloroacetimidate 

Downstream Products

• 117095-82-6 4-phenyl-2,6-pyridinedicarboxylic acid diethyl ester 
• 302-72-7 rac-Ala-OH 
• 1116585-86-4 ethyl (5Z)-5-(phenylimino)-5H-1,2,3-dithiazole-4-carboxylate 
• 6168-72-5 2-Amino-1-propanol 
• 58581-57-0 2-Hydroxyamino-propionic acid ethyl ester 
• 114775-54-1 2-[(E)-2-Chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-isoindol-2-yl)-4-fluoro-benzyloxyimino]-propionic acid ethyl ester 
• 23502-03-6 Ethyl-α-benzoyloximinopropionat 
• 1057667-61-4 N-[(ethyl oximinopropionate-2-yl)carbonyl]-1,1-dimethyl-2-phenyl ethylamine 
• 1057667-52-3 N-[(ethyl oximinopropionate-2-yl)carbonyl]-4-amino-3-(4-chloro-phenyl)-butanoic acid 
• 1057667-42-1 N-[(ethyl oximinopropionate-2-yl)carbonyl]-1-aminomethyl cyclohexaneacetic acid 

Relevant articles and documents

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Synthesis of c(αα)-unsymmetrically disubstituted nitroesters by electron transfer C-alkylation of ethyl 2-nitropropionate anion

The ethyl 2-nitropropionate anion was shown to react with six reductive alkylating agents to give new C(αα)-unsymmetrically disubstituted nitroesters and in some cases new ethyl monosubstituted methacrylates. The C- alkylation was shown to proceed by the S(RN)1 mechanism which was confirmed by the classical criteria for S(RN)1 reaction: the electron-withdrawing group effect and classical inhibition experiments by dioxygen, p-dinitrobenzene, cupric chloride or TEMPO. For example, ethyl 2-methyl-2-nitro-3-p- nitrophenylpropionate was transformed in the corresponding amino acid.

Concise Total Synthesis of Trichodermamides A, B, and C Enabled by an Efficient Construction of the 1,2-Oxazadecaline Core

We report herein a facile and efficient method of the construction of the cis-1,2-oxazadecaline system, distinctive of (pre)trichodermamides, aspergillazine A, gliovirin, and FA-2097. The formation of the 1,2-oxazadecaline core was accomplished by a 1,2-addition of an αC-lithiated O-silyl ethyl pyruvate oxime to benzoquinone, which is followed by an oxa-Michael ring-closure. The method was successfully applied to the concise total synthesis of trichodermamide A (in gram quantities) and trichodermamide B, as well as the first synthesis of trichodermamide C.

Exploring Tuning of Structural and Magnetic Properties by Modification of Ancillary β-Diketonate Co-ligands in a Family of Near-Linear Tetranuclear DyIII Complexes

Three tetranuclear DyIII complexes, [Dy4(LH)2(CH3OH)4(acac)6] (1), [Dy4(LH)2(CH3OH)4(hmacac)6]·2CH3OH (2), and [Dy4(LH)2(CH3OH)4(dpacac)6]·2CHCl3·2CH3OH·2H2O (3), have been synthesized and characterized [LH4 = (2E,N′E)-N′-(2,3-dihydroxybenzylidene)-2-(hydroxyimino)propanehydrazide; acacH = acetylacetone; hmacacH = 2,2,6,6-tetramethyl-3,5-heptanedione; dpacacH = dibenzoylmethane]. The structural elucidation of these complexes reveals two types of DyIII centers in terms of the number of ancillary β-diketonate co-ligands coordinated to the metal centers. Detailed magnetic studies have been carried out on 1-3 which reveal a slow relaxation of magnetization at low temperatures. The relaxation of complexes 2 and 3 is distributed in three temperature ranges: lower temperature process, transition range, and higher temperature process. In the higher temperature range, the best fitting of the data for 2 yields τ0 = (6.3 ± 3.6) × 10-6 s and Ueff = (23.8 ± 4.0) K, and for 3, τ0 = (9.4 ± 5.9) × 10-6 s, Ueff = (29.0 ± 6.3) K.

Modulating the magnetization dynamics of rare earth complexes by structural regulation utilizing different solvents

Five novel di- and tetra-nuclear rare earth complexes were synthesized by the variation of the solvent molecules: [Nd2(dbm)2(L)2(CH3OH)2]·0.75CH3OH (1), [Dy2(dbm)2(L)

Copper-Catalyzed Annulation of Oxime Acetates with α-Amino Acid Ester Derivatives: Synthesis of 3-Sulfonamido/Imino 4-Pyrrolin-2-ones

A copper-catalyzed annulation of oxime acetates and α-amino acid ester derivatives for the easy preparation of 4-pyrrolin-2-ones bearing a 3-amino group has been developed. This process features the oxidation of amines with oxime esters as the internal oxidant to produce the active 1,3-dinucleophilic and 1,2-dielectrophilic species concurrently. The subsequent nucleophilic cyclization realizes the efficient construction of 4-pyrrolin-2-one derivatives.